Howard Hughes Medical Institute
Color Variation Over Time in Rock Pocket Mouse Populations
Simple characteristic changes can have a significant impact on species survival. A hands-on activity has learners investigate the color variation in pocket mouse populations in different environments. They connect the timing and number...
Howard Hughes Medical Institute
Fact Patterns: A Film Guide
What does it take to create a scientific theory? Learners attempt to answer the question by studying the work of Charles Darwin and Alfred Russel Wallace. While watching a video, they track observations from each scientist and then look...
Howard Hughes Medical Institute
Testing a Hypothesis
Are sickle cell disease and malaria related somehow? Scholars learn about both illnesses and the hypotheses that they are related. They discuss, view a video, and answer questions to demonstrate understanding. The resource includes an...
Howard Hughes Medical Institute
Color Variation Over Time in Rock Pocket Mouse Populations
While many mutations are neutral, those that appear advantageous increase in frequency in a population. Scholars use illustrations to make predictions about populations of mice. They follow it up with a video to confirm or refute their...
Howard Hughes Medical Institute
Molecular Genetics of Color Mutations in Rock Pocket Mice
Can you identify mutations just by viewing DNA sequences? Scholars apply prior knowledge of DNA sequences to do just that in an engaging activity. They transcribe and translate genes, thus identifying the locations of mutations. Then,...
Howard Hughes Medical Institute
Biochemistry and Cell Signaling Pathway of the Mc1r Gene
How do mice have so much fur color variation over generations? Scholars illustrate protein structures based on amino acid sequences. Then, they analyze the signaling pathway in different-colored mice populations. This allows them to...
Howard Hughes Medical Institute
Natural Selection and Evolution of Rock Pocket Mouse Populations
Can evolution repeat itself? Scholars analyze amino acid data in two separate populations of mice. They learn that evolution repeats itself, but natural selection prefers some mutations over others in different environments. Analysis...
Howard Hughes Medical Institute
The Molecular Evolution of Gene Birth and Death
More than 90 percent of humans' DNA doesn't code for anything! Scholars watch a presentation as they answer questions relating to gene mutations. They read details, watch videos, and view animations supporting the concepts. The questions...
Howard Hughes Medical Institute
Icefish Blood Adaptations: Viscosity
Most fish freeze to death when the water is too cold, yet some fish live in the Southern Ocean where the water is often below freezing. Scholars use two models representing the blood from most fish versus the blood from Antarctic fish....
Howard Hughes Medical Institute
How Do Fibers Form?
The proteins inside a cell determine the shape of the cell. While most red blood cells have a circular shape, those with sickle cell take the shape of a sickle. This change in shape causes multiple issues in the system. Scholars solve...
Howard Hughes Medical Institute
Population Genetics, Selection, and Evolution
The Hardy-Weinberg principle states that alleles and genotypes remain constant in the absence of evolutionary influences. Scholars complete a simple hands-on activity applying the Hardy-Weinberg principle to sample data. They observe how...
Cold Spring Harbor Laboratory
Evolution Begins with the Inheritance of Gene Variations
Connect Mendelian genetics with Darwinian theories. An interactive lesson lets pupils explore how George Shull used research from other scientists to explore genetic variation. The resource outlines the statistical analysis of genetic...
Serendip
The Ecology of Lyme Disease
Areas that previously included no risk of Lyme disease now have cases every year. Scholars learn about the spread of Lyme disease and the relationship with ecological succession. Then, they discuss possible solutions using the known food...
Serendip
Evolution of Fur Color in Mice – Mutation, Environment and Natural Selection
Most species of animals include a variety of fur or hair color, but why? Scholars watch a video about a changing environment for mice. As the rocks around them change hues, different colors of mice begin to thrive. Discussion questions...
Serendip
How Eyes Evolved – Analyzing the Evidence
Octopodes existed for hundreds of thousands of years before humans, yet our eyes share many similarities. Scholars analyze the evidence to determine if the evolution of eyes best fits a homology or analogy model. They discuss the issue...
Howard Hughes Medical Institute
Evolution in Action: Data Analysis
An environmental factor, such as a drought, sometimes speeds up the rate of natural selection. Scholars analyze data on the beaks of birds around the time of the drought. They compare those that survived to those that perished and find...
Howard Hughes Medical Institute
Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish
Gene switches work similarly to light switches in controlling one feature of their environments. Scholars study the Pitx1 gene in a specific type of fish. They learn the different ways this switch controls various body parts and...
Howard Hughes Medical Institute
Stickleback Evolution Virtual Lab
How quickly do animals evolve? Can comparing different samples of the same fossil answer timeline questions? Scholars use virtual labs to examine fossils and learn about stickleback evolution. They compare pelvic morphology in lakes...
Howard Hughes Medical Institute
Mendelian Genetics, Probability, Pedigree, and Chi-Square Statistics
People with the sickle cell trait, but not sickle cell disease, find natural protection against malaria. Scholars consider various combinations of genotypes and environmental factors to determine if children might have sickle cell...
Biology Junction
Population Genetics
Genetic variation shows the health of a population, yet cheetahs show very little variation over that last 10,000 years. Scholars learn the importance of genetic variation in populations after viewing an informative presentation. It...
Biology Junction
Lamarck vs. Darwin: Introduction to Change in Organisms
How are traits passed down from parents? Jean Baptiste Lamarck and Charles Darwin envisioned conflicting theories. Learn about both scientists and their theories with an insightful presentation. Giraffes and dogs serve as examples of...
Biology Junction
Evolution – Diversity of Life
Scientists noticed animals with backbones share similar bone structure despite having different forms, such as fins, arms, and wings. Young scientists gain an appreciation for evolution by understanding the history of the theory. They...
Howard Hughes Medical Institute
Reading Primary Sources: Darwin and Wallace
Take your classes back in time. Learners read real historical texts from both Darwin and Wallace as well as an announcement of their findings. Using guiding questions, they make inferences and draw conclusions from the information in the...
Howard Hughes Medical Institute
Look Who's Coming for Dinner: Selection by Predation
What happens when a new predator comes to town? Learners analyze an experiment that studies the effect of predation on selection. They use real data to draw conclusions about the impact a new predator has on a prey species.