Lesson Plan
Serendip

The Molecular Biology of Mutations and Muscular Dystrophy

For Teachers 9th - 12th
Different types of mutations cause unique types and degrees of muscular dystrophy. Scholars learn about the types of mutations and the impact on the body. They compare the location of the mutations and draw conclusions about how it is...
Lesson Plan
Serendip

UV, Mutations, and DNA Repair

For Teachers 9th - 12th
How effective are cells at repairing UV damage? An inquiry-based activity has learners experiment with organism by exposing them to various levels of UV light and then examining their DNA after a period of time. Pupils test different...
Activity
Howard Hughes Medical Institute

Natural Selection and Evolution of Rock Pocket Mouse Populations

For Teachers 9th - 12th Standards
Can evolution repeat itself? Scholars analyze amino acid data in two separate populations of mice. They learn that evolution repeats itself, but natural selection prefers some mutations over others in different environments. Analysis...
Activity
Howard Hughes Medical Institute

Natural Selection and the Evolution of Darwin's Finches

For Teachers 6th - 12th Standards
Darwin explained the connection between species of finches 150 years before scientists understood DNA. Technology and progressing science proved he was right, yet many struggle to understand how natural selection happens. Scholars use...
Lesson Plan10:25
Howard Hughes Medical Institute

The Making of the Fittest: Natural Selection and Adaptation

For Students 8th - Higher Ed Standards
The pocket mouse can be light brown like the sands of the desert, or dark brown like the volcanic lava flows that are interspersed throughout New Mexico's Valley of Fire. It seems that predators have weeded out light colored mice in this...
Activity
Howard Hughes Medical Institute

Molecular Genetics of Color Mutations in Rock Pocket Mice

For Teachers 9th - 12th Standards
Can you identify mutations just by viewing DNA sequences? Scholars apply prior knowledge of DNA sequences to do just that in an engaging activity. They transcribe and translate genes, thus identifying the locations of mutations. Then,...
Activity
Howard Hughes Medical Institute

The Molecular Evolution of Gene Birth and Death

For Teachers 9th - 12th Standards
More than 90 percent of humans' DNA doesn't code for anything! Scholars watch a presentation as they answer questions relating to gene mutations. They read details, watch videos, and view animations supporting the concepts. The questions...
Activity
Howard Hughes Medical Institute

Ebola: Disease Detectives

For Teachers 9th - Higher Ed
How did the Ebola virus first infect humans? Young virologists examine genetic sequences from the 2014 Sierra Leone outbreak to find similarities during a riveting activity. Following similar methods used by MIT and Harvard, partners...
Lesson Plan
Howard Hughes Medical Institute

Icefish Adaptations

For Teachers 7th - 12th Standards
What adaptations exist in order for icefish to survive the subfreezing temperatures of the Antarctic Ocean? Middle and high schoolers can find out through watching a related 13-minute video and performing a simple investigation to...
Lesson Plan
Serendip

Using Molecular and Evolutionary Biology to Understand HIV/AIDS and Treatment

For Teachers 9th - 12th Standards
HIV mutates rapidly, making treatments challenging to find. Scholars learn about why it mutates so quickly and how scientists race to find treatments. The resource approaches the issue from both a molecular and evolutionary perspective...
Activity
American Museum of Natural History

Microbes Coloring Book and Scavenger Hunt

For Students 6th - 12th
Coloring pages showcase microbes—bacteria, viruses, and protists. Scholars have the option to download a coloring book and scavenger hunt or color the page directly on the computer. Three paragraphs describe each microbe. 
Activity
Howard Hughes Medical Institute

Stalking the Genetic Basis of a Trait

For Teachers 9th - 12th Standards
Need an a-maize-ing lesson to show your class how regulatory genes work? If you use the well-written resource, they'll be all ears! Biology scholars discover the gene responsible for the evolution of the modern-day corn plant through a...
Activity
Howard Hughes Medical Institute

Lactase Persistence: Evidence for Selection

For Teachers 9th - 12th Standards
What's the link between lactase persistence and dairy farming? Biology scholars analyze data to find evidence of the connection, then relate this to human adaptation. Working individually and in small groups, learners view short video...
Activity
Howard Hughes Medical Institute

Icefish Blood Adaptations: Viscosity

For Teachers 9th - 12th Standards
Most fish freeze to death when the water is too cold, yet some fish live in the Southern Ocean where the water is often below freezing. Scholars use two models representing the blood from most fish versus the blood from Antarctic fish....
Lesson Plan
Serendip

Understanding the Biology of Cancer

For Teachers 9th - 12th Standards
After initial exposure to a carcinogen, a cancer diagnosis often takes more than a decade due to the slow buildup of mutated cells in the body. Scholars learn about the biology of cancer with a worksheet and discussion questions. They...
Activity
Howard Hughes Medical Institute

Color Variation Over Time in Rock Pocket Mouse Populations

For Teachers 9th - 12th Standards
While many mutations are neutral, those that appear advantageous increase in frequency in a population. Scholars use illustrations to make predictions about populations of mice. They follow it up with a video to confirm or refute their...
Activity
Howard Hughes Medical Institute

Icefish Blood Adaptations: Antifreeze Proteins

For Teachers 9th - 12th
Ever wonder how fish survive in freezing cold water—especially Antarctic waters? Some fish have an adaptation that lowers the freezing point of their life fluids. Learners model these adaptations in two lab explorations. The first...
Activity
Howard Hughes Medical Institute

Testing a Hypothesis

For Students 9th - 12th Standards
Are sickle cell disease and malaria related somehow? Scholars learn about both illnesses and the hypotheses that they are related. They discuss, view a video, and answer questions to demonstrate understanding. The resource includes an...
Activity
Curated OER

Activity: Gummy Bear Genetics

For Students 9th - 12th Standards
Who's your Daddy ... and Mommy for that matter? Given a first-generation group of gummy bear offspring, young scientists must determine which bears are their parents. An activity worksheet covers the differences in genotypes and...
Activity
Howard Hughes Medical Institute

HIV Protease Inhibitors

For Teachers 9th - 12th
How do doctors fight a virus that's constantly mutating? Show science scholars how we fight HIV using one of its own most fundamental processes through a thoughtful demonstration. The lesson focuses on how protease inhibitors prevent HIV...
Activity
Howard Hughes Medical Institute

Biochemistry and Cell Signaling Pathway of the Mc1r Gene

For Teachers 9th - 12th Standards
How do mice have so much fur color variation over generations? Scholars illustrate protein structures based on amino acid sequences. Then, they analyze the signaling pathway in different-colored mice populations. This allows them to...
Activity
Howard Hughes Medical Institute

How Do Fibers Form?

For Teachers 9th - 12th Standards
The proteins inside a cell determine the shape of the cell. While most red blood cells have a circular shape, those with sickle cell take the shape of a sickle. This change in shape causes multiple issues in the system. Scholars solve...
Activity
Howard Hughes Medical Institute

Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

For Teachers 9th - 12th Standards
Gene switches work similarly to light switches in controlling one feature of their environments. Scholars study the Pitx1 gene in a specific type of fish. They learn the different ways this switch controls various body parts and...
Activity
Howard Hughes Medical Institute

Developing an Explanation for Mouse Fur Color

For Teachers 7th - 12th Standards
Whether or not you think mice are nice, you'll love the colorful activity! Scholars examine evidence for evolution in the rock pocket mouse through video, discussion, and collaborative work. Learners watch a video regarding variation in...

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