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Serendip
The Molecular Biology of Mutations and Muscular Dystrophy
Different types of mutations cause unique types and degrees of muscular dystrophy. Scholars learn about the types of mutations and the impact on the body. They compare the location of the mutations and draw conclusions about how it is...
Serendip
UV, Mutations, and DNA Repair
How effective are cells at repairing UV damage? An inquiry-based activity has learners experiment with organism by exposing them to various levels of UV light and then examining their DNA after a period of time. Pupils test different...
Howard Hughes Medical Institute
Natural Selection and Evolution of Rock Pocket Mouse Populations
Can evolution repeat itself? Scholars analyze amino acid data in two separate populations of mice. They learn that evolution repeats itself, but natural selection prefers some mutations over others in different environments. Analysis...
Howard Hughes Medical Institute
Natural Selection and the Evolution of Darwin's Finches
Darwin explained the connection between species of finches 150 years before scientists understood DNA. Technology and progressing science proved he was right, yet many struggle to understand how natural selection happens. Scholars use...
Howard Hughes Medical Institute
The Making of the Fittest: Natural Selection and Adaptation
The pocket mouse can be light brown like the sands of the desert, or dark brown like the volcanic lava flows that are interspersed throughout New Mexico's Valley of Fire. It seems that predators have weeded out light colored mice in this...
Howard Hughes Medical Institute
Molecular Genetics of Color Mutations in Rock Pocket Mice
Can you identify mutations just by viewing DNA sequences? Scholars apply prior knowledge of DNA sequences to do just that in an engaging activity. They transcribe and translate genes, thus identifying the locations of mutations. Then,...
Howard Hughes Medical Institute
The Molecular Evolution of Gene Birth and Death
More than 90 percent of humans' DNA doesn't code for anything! Scholars watch a presentation as they answer questions relating to gene mutations. They read details, watch videos, and view animations supporting the concepts. The questions...
Howard Hughes Medical Institute
Ebola: Disease Detectives
How did the Ebola virus first infect humans? Young virologists examine genetic sequences from the 2014 Sierra Leone outbreak to find similarities during a riveting activity. Following similar methods used by MIT and Harvard, partners...
Howard Hughes Medical Institute
Icefish Adaptations
What adaptations exist in order for icefish to survive the subfreezing temperatures of the Antarctic Ocean? Middle and high schoolers can find out through watching a related 13-minute video and performing a simple investigation to...
Serendip
Using Molecular and Evolutionary Biology to Understand HIV/AIDS and Treatment
HIV mutates rapidly, making treatments challenging to find. Scholars learn about why it mutates so quickly and how scientists race to find treatments. The resource approaches the issue from both a molecular and evolutionary perspective...
American Museum of Natural History
Microbes Coloring Book and Scavenger Hunt
Coloring pages showcase microbes—bacteria, viruses, and protists. Scholars have the option to download a coloring book and scavenger hunt or color the page directly on the computer. Three paragraphs describe each microbe.
Howard Hughes Medical Institute
Stalking the Genetic Basis of a Trait
Need an a-maize-ing lesson to show your class how regulatory genes work? If you use the well-written resource, they'll be all ears! Biology scholars discover the gene responsible for the evolution of the modern-day corn plant through a...
Howard Hughes Medical Institute
Lactase Persistence: Evidence for Selection
What's the link between lactase persistence and dairy farming? Biology scholars analyze data to find evidence of the connection, then relate this to human adaptation. Working individually and in small groups, learners view short video...
Howard Hughes Medical Institute
Icefish Blood Adaptations: Viscosity
Most fish freeze to death when the water is too cold, yet some fish live in the Southern Ocean where the water is often below freezing. Scholars use two models representing the blood from most fish versus the blood from Antarctic fish....
Serendip
Understanding the Biology of Cancer
After initial exposure to a carcinogen, a cancer diagnosis often takes more than a decade due to the slow buildup of mutated cells in the body. Scholars learn about the biology of cancer with a worksheet and discussion questions. They...
Howard Hughes Medical Institute
Color Variation Over Time in Rock Pocket Mouse Populations
While many mutations are neutral, those that appear advantageous increase in frequency in a population. Scholars use illustrations to make predictions about populations of mice. They follow it up with a video to confirm or refute their...
Howard Hughes Medical Institute
Icefish Blood Adaptations: Antifreeze Proteins
Ever wonder how fish survive in freezing cold water—especially Antarctic waters? Some fish have an adaptation that lowers the freezing point of their life fluids. Learners model these adaptations in two lab explorations. The first...
Howard Hughes Medical Institute
Testing a Hypothesis
Are sickle cell disease and malaria related somehow? Scholars learn about both illnesses and the hypotheses that they are related. They discuss, view a video, and answer questions to demonstrate understanding. The resource includes an...
Curated OER
Activity: Gummy Bear Genetics
Who's your Daddy ... and Mommy for that matter? Given a first-generation group of gummy bear offspring, young scientists must determine which bears are their parents. An activity worksheet covers the differences in genotypes and...
Howard Hughes Medical Institute
HIV Protease Inhibitors
How do doctors fight a virus that's constantly mutating? Show science scholars how we fight HIV using one of its own most fundamental processes through a thoughtful demonstration. The lesson focuses on how protease inhibitors prevent HIV...
Howard Hughes Medical Institute
Biochemistry and Cell Signaling Pathway of the Mc1r Gene
How do mice have so much fur color variation over generations? Scholars illustrate protein structures based on amino acid sequences. Then, they analyze the signaling pathway in different-colored mice populations. This allows them to...
Howard Hughes Medical Institute
How Do Fibers Form?
The proteins inside a cell determine the shape of the cell. While most red blood cells have a circular shape, those with sickle cell take the shape of a sickle. This change in shape causes multiple issues in the system. Scholars solve...
Howard Hughes Medical Institute
Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish
Gene switches work similarly to light switches in controlling one feature of their environments. Scholars study the Pitx1 gene in a specific type of fish. They learn the different ways this switch controls various body parts and...
Howard Hughes Medical Institute
Developing an Explanation for Mouse Fur Color
Whether or not you think mice are nice, you'll love the colorful activity! Scholars examine evidence for evolution in the rock pocket mouse through video, discussion, and collaborative work. Learners watch a video regarding variation in...
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