Lesson Plan10:25
Howard Hughes Medical Institute

The Making of the Fittest: Natural Selection and Adaptation

For Students 8th - Higher Ed Standards
The pocket mouse can be light brown like the sands of the desert, or dark brown like the volcanic lava flows that are interspersed throughout New Mexico's Valley of Fire. It seems that predators have weeded out light colored mice in this...
Lesson Plan15:27
Howard Hughes Medical Institute

The Making of the Fittest: Evolving Switches, Evolving Bodies

For Teachers 9th - Higher Ed Standards
How did the stickleback fish, which was once ocean bound, evolve to be able to persist in freshwater lakes? Hear from the scientists who identified the genes and related switches that allowed these survivors to adapt. In addition to the...
Lesson Plan14:52
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Howard Hughes Medical Institute

The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture

For Teachers 8th - Higher Ed Standards
Got milk? Only two cultures have had it long enough to develop the tolerance of lactose as an adult. Learn how the responsible genes evolved along with the cultures that have been consuming milk. This rich film is supplied with a few...
Activity
Howard Hughes Medical Institute

Natural Selection and the Evolution of Darwin's Finches

For Teachers 6th - 12th Standards
Darwin explained the connection between species of finches 150 years before scientists understood DNA. Technology and progressing science proved he was right, yet many struggle to understand how natural selection happens. Scholars use...
Lesson Plan
Curated OER

The Effect of Natural Selection on Genes, Traits and Individuals

For Teachers 9th - 12th Standards
Rotating through five stations, evolutionary biologists explore the question of how changes in DNA facilitate the changes in a population over time. High-quality, colorful cards of animals, skeletons, skulls, and DNA sequences can all be...
Activity
Howard Hughes Medical Institute

Stalking the Genetic Basis of a Trait

For Teachers 9th - 12th Standards
Need an a-maize-ing lesson to show your class how regulatory genes work? If you use the well-written resource, they'll be all ears! Biology scholars discover the gene responsible for the evolution of the modern-day corn plant through a...
Activity
Howard Hughes Medical Institute

Natural Selection and Evolution of Rock Pocket Mouse Populations

For Teachers 9th - 12th Standards
Can evolution repeat itself? Scholars analyze amino acid data in two separate populations of mice. They learn that evolution repeats itself, but natural selection prefers some mutations over others in different environments. Analysis...
Activity
Howard Hughes Medical Institute

Patterns in the Distribution of Lactase Persistence

For Teachers 9th - 12th Standards
We all drink milk as babies, so why can't we all drink it as adults? Examine the trend in lactase production on the world-wide scale as science scholars analyze and interpret data. Groups create pie charts from the data, place them on a...
Activity
Howard Hughes Medical Institute

Mendelian Genetics, Probability, Pedigree, and Chi-Square Statistics

For Teachers 9th - 12th Standards
People with the sickle cell trait, but not sickle cell disease, find natural protection against malaria. Scholars consider various combinations of genotypes and environmental factors to determine if children might have sickle cell...
Activity
Howard Hughes Medical Institute

Population Genetics, Selection, and Evolution

For Teachers 9th - 12th Standards
The Hardy-Weinberg principle states that alleles and genotypes remain constant in the absence of evolutionary influences. Scholars complete a simple hands-on activity applying the Hardy-Weinberg principle to sample data. They observe how...
Activity
Howard Hughes Medical Institute

Molecular Genetics of Color Mutations in Rock Pocket Mice

For Teachers 9th - 12th Standards
Can you identify mutations just by viewing DNA sequences? Scholars apply prior knowledge of DNA sequences to do just that in an engaging activity. They transcribe and translate genes, thus identifying the locations of mutations. Then,...
Activity
Howard Hughes Medical Institute

The Molecular Evolution of Gene Birth and Death

For Teachers 9th - 12th Standards
More than 90 percent of humans' DNA doesn't code for anything! Scholars watch a presentation as they answer questions relating to gene mutations. They read details, watch videos, and view animations supporting the concepts. The questions...
Activity
Howard Hughes Medical Institute

Lactase Persistence: Evidence for Selection

For Teachers 9th - 12th Standards
What's the link between lactase persistence and dairy farming? Biology scholars analyze data to find evidence of the connection, then relate this to human adaptation. Working individually and in small groups, learners view short video...
Activity
Howard Hughes Medical Institute

Understanding Variation

For Teachers 9th - Higher Ed Standards
Does where we live influence how our bodies express genetic traits? Explore variation in human skin color with an activity that incorporate video and hands-on learning. Individuals model the relationship between phenotypes and genotypes,...
Activity
Howard Hughes Medical Institute

Developing an Explanation for Mouse Fur Color

For Teachers 7th - 12th Standards
Whether or not you think mice are nice, you'll love the colorful activity! Scholars examine evidence for evolution in the rock pocket mouse through video, discussion, and collaborative work. Learners watch a video regarding variation in...
Activity
Howard Hughes Medical Institute

Zebrafish and Skin Color

For Teachers 9th - Higher Ed
You may not know if that zebrafish in your fish tank is a model citizen—but it is definitely a model organism! What can we learn about ourselves from a tiny zebrafish? Discover more about the polygenic trait of skin color through a...
Activity
Howard Hughes Medical Institute

Stickleback Evolution Virtual Lab

For Students 9th - 12th Standards
How quickly do animals evolve? Can comparing different samples of the same fossil answer timeline questions? Scholars use virtual labs to examine fossils and learn about stickleback evolution. They compare pelvic morphology in lakes...
Activity
Discovery Education

Blueprint for Life

For Teachers 6th - 8th
DNA is the code for all biological traits, both plant and animal. Using an exploratory lesson, learners begin to explore the concept of a biological code by decoding word puzzles. They then extract DNA from plant cells using detergent to...
Activity
Howard Hughes Medical Institute

Lactose Intolerance: Fact or Fiction

For Teachers 7th - 12th Standards
Around the world, about 2/3 of adult humans are lactose intolerant. Scholars work in small groups to discuss a few statements about lactose intolerance. Then, they watch a video on the topic and readdress each statement. Whole-class...
Activity
Howard Hughes Medical Institute

Reading Primary Sources: Darwin and Wallace

For Teachers 9th - 12th Standards
Take your classes back in time. Learners read real historical texts from both Darwin and Wallace as well as an announcement of their findings. Using guiding questions, they make inferences and draw conclusions from the information in the...
Activity
Howard Hughes Medical Institute

Color Variation Over Time in Rock Pocket Mouse Populations

For Teachers 9th - 12th Standards
Simple characteristic changes can have a significant impact on species survival. A hands-on activity has learners investigate the color variation in pocket mouse populations in different environments. They connect the timing and number...
Activity
Howard Hughes Medical Institute

Icefish Blood Adaptations: Antifreeze Proteins

For Teachers 9th - 12th
Ever wonder how fish survive in freezing cold water—especially Antarctic waters? Some fish have an adaptation that lowers the freezing point of their life fluids. Learners model these adaptations in two lab explorations. The first...
Activity
Howard Hughes Medical Institute

Biochemistry and Cell Signaling Pathway of the Mc1r Gene

For Teachers 9th - 12th Standards
How do mice have so much fur color variation over generations? Scholars illustrate protein structures based on amino acid sequences. Then, they analyze the signaling pathway in different-colored mice populations. This allows them to...
Activity
Howard Hughes Medical Institute

Ebola: Disease Detectives

For Teachers 9th - Higher Ed
How did the Ebola virus first infect humans? Young virologists examine genetic sequences from the 2014 Sierra Leone outbreak to find similarities during a riveting activity. Following similar methods used by MIT and Harvard, partners...