Activity
Howard Hughes Medical Institute

The Molecular Evolution of Gene Birth and Death

For Teachers 9th - 12th Standards
More than 90 percent of humans' DNA doesn't code for anything! Scholars watch a presentation as they answer questions relating to gene mutations. They read details, watch videos, and view animations supporting the concepts. The questions...
Activity
Howard Hughes Medical Institute

Molecular Genetics of Color Mutations in Rock Pocket Mice

For Teachers 9th - 12th Standards
Can you identify mutations just by viewing DNA sequences? Scholars apply prior knowledge of DNA sequences to do just that in an engaging activity. They transcribe and translate genes, thus identifying the locations of mutations. Then,...
Lesson Plan
Serendip

The Molecular Biology of Mutations and Muscular Dystrophy

For Teachers 9th - 12th
Different types of mutations cause unique types and degrees of muscular dystrophy. Scholars learn about the types of mutations and the impact on the body. They compare the location of the mutations and draw conclusions about how it is...
Activity
Howard Hughes Medical Institute

Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

For Teachers 9th - 12th Standards
Gene switches work similarly to light switches in controlling one feature of their environments. Scholars study the Pitx1 gene in a specific type of fish. They learn the different ways this switch controls various body parts and...
Activity
Howard Hughes Medical Institute

Stalking the Genetic Basis of a Trait

For Teachers 9th - 12th Standards
Need an a-maize-ing lesson to show your class how regulatory genes work? If you use the well-written resource, they'll be all ears! Biology scholars discover the gene responsible for the evolution of the modern-day corn plant through a...
Activity
Howard Hughes Medical Institute

HIV Protease Inhibitors

For Teachers 9th - 12th
How do doctors fight a virus that's constantly mutating? Show science scholars how we fight HIV using one of its own most fundamental processes through a thoughtful demonstration. The lesson focuses on how protease inhibitors prevent HIV...
Lesson Plan
Serendip

UV, Mutations, and DNA Repair

For Teachers 9th - 12th
How effective are cells at repairing UV damage? An inquiry-based lesson has learners experiment with organism by exposing them to various levels of UV light and then examining their DNA after a period of time. Pupils test different...
Activity
Howard Hughes Medical Institute

Natural Selection and Evolution of Rock Pocket Mouse Populations

For Teachers 9th - 12th Standards
Can evolution repeat itself? Scholars analyze amino acid data in two separate populations of mice. They learn that evolution repeats itself, but natural selection prefers some mutations over others in different environments. Analysis...
Activity
Howard Hughes Medical Institute

Biochemistry and Cell Signaling Pathway of the Mc1r Gene

For Teachers 9th - 12th Standards
How do mice have so much fur color variation over generations? Scholars illustrate protein structures based on amino acid sequences. Then, they analyze the signaling pathway in different-colored mice populations. This allows them to...
Activity
Howard Hughes Medical Institute

Cancer Discovery Activities

For Teachers 9th - 12th
Explore the genetic component of the second-leading cause of death in the world using a hands-on activity. After watching a video discussing the basics of cancer, learners complete activities that study the genes involved in cancer. The...
Lesson Plan
Serendip

Using Molecular and Evolutionary Biology to Understand HIV/AIDS and Treatment

For Teachers 9th - 12th Standards
HIV mutates rapidly, making treatments challenging to find. Scholars learn about why it mutates so quickly and how scientists race to find treatments. The resource approaches the issue from both a molecular and evolutionary perspective...
Lesson Plan10:25
Howard Hughes Medical Institute

The Making of the Fittest: Natural Selection and Adaptation

For Students 8th - Higher Ed Standards
The pocket mouse can be light brown like the sands of the desert, or dark brown like the volcanic lava flows that are interspersed throughout New Mexico's Valley of Fire. It seems that predators have weeded out light colored mice in this...
Activity
Howard Hughes Medical Institute

Lactase Persistence: Evidence for Selection

For Teachers 9th - 12th Standards
What's the link between lactase persistence and dairy farming? Biology scholars analyze data to find evidence of the connection, then relate this to human adaptation. Working individually and in small groups, learners view short video...
Activity
Howard Hughes Medical Institute

Developing an Explanation for Mouse Fur Color

For Teachers 7th - 12th Standards
Whether or not you think mice are nice, you'll love the colorful activity! Scholars examine evidence for evolution in the rock pocket mouse through video, discussion, and collaborative work. Learners watch a video regarding variation in...
Activity
Curated OER

Activity: Gummy Bear Genetics

For Students 9th - 12th Standards
Who's your Daddy ... and Mommy for that matter? Given a first-generation group of gummy bear offspring, young scientists must determine which bears are their parents. An activity worksheet covers the differences in genotypes and...
Activity
National Health Museum

Access Excellence: Genes, Dna, and Mutations

For Students 9th - 10th
A good Access Excellence site with an introduction to the processes of transcription and translation, leading to a student modeling activity.

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