Lesson Plan

The Innate Immune System

Curated and Reviewed by Lesson Planet

My body is my castle. Pupils learn about the innate immune system in the second lesson plan of a three-part unit on the immune system by comparing the innate immune system to a castle and moat. Groups conduct a simulation where they try to get different types of balls representing pathogens into a box protected by tape representing the immune system. Scholars make a comparison of the castle and moat game to the first line of defense against pathogens.

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CCSS: Designed
NGSS: Designed
Additional Tags
Instructional Ideas
  • Ask the class why they think it is important for mucous membranes to replenish the mucous frequently
Classroom Considerations
  • Assumes knowledge of calculating percentages and averages
  • Each group requires 10 of each of three different types of small balls 
  • To access the interactive game portion requires a free signup
  • Includes an answer key
  • Provides a glossary of terms
  • None