Cold Spring Harbor Laboratory
A Gene Is a Discrete Sequence of DNA Nucleotides
Frederick Sanger won two Nobel prizes for protein sequencing and DNA sequencing. Young scientists learn about Dr. Sanger's research and amazing discoveries. They read an article and a biography, view videos and animations, and apply...
Curated OER
The Watson-Crick Model of DNA Structure
Junior geneticists construct models of DNA to discover sequencing and pairing of nucleotides. They use the models to simulate protein synthesis and then translate the codes into physical traits. Finally, they use the traits to create a...
Curated OER
Using Amino Acid Sequences to Show Evolutionary Relationships
Junior biologists compare the amino acid sequences from fragments of five different globin molecules. They count the letter differences between each species pair. They construct a graphic representation of the evolutionary relationships...
Curated OER
Constructing a Phylogenetic Tree Using DNA Sequence Data
Students analyze DNA sequence differences between organisms in order to establish a reasonable picture of the evolutionary relationships between them. They take the role of molecular biologists and make genetic changes and constructing...
Curated OER
Sequencing the Cystic Fibrosis Gene: A Simulation
Ninth graders determine nucleotide sequences. They identify those base sequences that are normal, those that are normal variants and those that cause cystic fibrosis. Students use DNA nucleotide sequences to determine amino acid...
Curated OER
Embryology as Evidence of Evolution
Students observe the two major developmental pathways (protostome and deuterostome). They analyze data regarding differences in nucleotide sequences and construct a phylogenetic tree. They observe the similar evolutionary history shared...
Curated OER
Nucleic Acids: information storage
This sequence of slides covers each main macromolecule that is involved with human structure and function. The history of nucleotide research and the way that they are formed is summarized, a diagram accompanies the explanation. The main...
Curated OER
DNA Sequencing Simulation
Young scholars simulate the Sanger method of DNA sequencing using color pop-beads as a representation of nucleotides and dideoxynucleotides. Students assemble DNA sequences and run their sequences through a "sequencing gel" and sketch...
Curated OER
Using Amino Acid Sequences to Show Evolutionary Relationships
Compare protein fragments, count amino acids, and use the information to explore common ancestry. The resource mentions a student worksheet, however, a separate printable worksheet is not provided. The exercises are written into the...
Curated OER
Sequence Alignment
Young scholars explore the uses of sequence alignment. In this DNA instructional activity students complete several experiments on sequencing and algorithms.
Curated OER
AP: Chapter 20: DNA Technology
This nine-page biotechnology resource contains six pages of questions regarding DNA technology. Questions cover cloning, restriction enzymes, the polymerase chain reaction, different techniques, the human genome project, and more. The...
Curated OER
DNA Sequencing Simulation
Students explore the Sanger sequencing method which produces a nested set of radioactive fragments from a template strand. They simulate the Sanger method of sequencing DNA, both visually and kinesthetically.
Curated OER
Sequencing the Cystic Fibrosis Gene: A Simulation
Ninth graders use this activity to simulate the sequencing of gene and to detect the presence of possible genetic defects. They use diagrams that represent bands of nucleotides in order to determine the sequence of a small piece of the...
Curated OER
Transcription and Translation Lab Activity
Students investigate DNA strands. They study the sequence to determine if it is DNA or RNA and write the mRNA nucleotide sequence. After stringing the beads together to create the mRNA sequence they translate it into an amino acid...
Curated OER
Fly Forensics
Freddy's Friendly Fruit Market is under attack by fruit flies, and it is up to your aspiring biologists to solve the crime! By reading and analyzing the phenotypes, detectives determine which fly is responsible. This memorable assignment...
Serendip
DNA Structure, Function and Replication
Before a cell replicates, its DNA must replicate. Take advantage of a hands-on guided lesson to teach budding scientists how this happens. Using a set of nucleotide cards, learners become the DNA and work to create matching strands...
Curated OER
Nucleic Acid
In this chromosome activity students complete a crossword puzzle by answering questions on DNA, nucleic acids, nucleotides and RNA.
Curated OER
From Gene to Protein ~ Transcription and Translation
Translate the process of protein synthesis to your molecular biologists with this instructional activity. It consists of reading, completing a table as a summary, comprehension questions, and a modeling activity for both transcription...
Curated OER
DNA Dry Lab
Students use a DNA strand to identify the component parts. They discuss an RNA molecule, protein fragments, and nucleotides. They explore how the order of nucleotides determines the order of amino acids in proteins.
Howard Hughes Medical Institute
Viral DNA Integration
How do reverse transcriptase inhibitors work? Young virologists examine the function of azidothymidine, a drug doctors use to treat HIV patients, during a hands-on modeling activity. Groups create a strand of DNA from an HIV RNA strand...
Cold Spring Harbor Laboratory
The RNA Message Is Sometimes Edited
In 1993, Phillip Sharp and Richard Roberts won the Nobel Prize for their discovery of split gene theory. Learn about the breakthrough with the help of an online interactive. Hear both scientists explain it in their own words, watch an...
Exploratorium
Secret Codon - Write a Message in DNA
String up a message. Pupils string together colored beads to code a word or short phrase. Each color represents one of the four DNA bases. Using a combination of three bases, learners create an amino acid that stand for each letter of...
Curated OER
The Coding of Protein Molecules by DNA
Students investigate the production of proteins by the DNA. In this protein synthesis lesson plan, students use paper models to explore transcription and translation to make proteins using DNA. Students answer 10 questions to demonstrate...
Curated OER
RNA Worksheet
In this RNA worksheet, learners determine the function of mRNA and tRNA and create an mRNA strand from a given DNA strand. Students describe and compare the 3 types of RNA. This worksheet has 1 drawing, 2 fill in the blank, and 14 short...