Crash Course
Crossed Aldol Reactions, Enones, and Conjugate Addition: Crash Course Organic Chemistry
Insects can communicate with each other about all kinds of things, but instead of using words, they use… you guessed it! Organic Chemistry! Insects can send signals to each other by secreting compounds, and one such compound used by...
Crash Course
Enols and Enolates - Reactivity, Halogenation, and Alkylation: Crash Course Organic Chemistry
You may know that cows produce methane, which is a big concern when it comes to global heating, but did you know that organic chemistry provides a potential solution to this problem? Feeding cows small amounts of red seaweed can greatly...
Crash Course
Carboxylic Acid Derivatives - Interconversion & Organometallics: Crash Course Organic Chemistry
We get it, learning so many different organic reactions is probably giving you a headache, but hopefully this episode can help! We’re getting even deeper into carboxylic acid derivatives, some of which are used in common headache...
Crash Course
An Overview of Aldehydes and Ketones: Crash Course Organic Chemistry
Ketones and aldehydes are all around and inside us, from the strong smelling component of nail polish remover, acetone, to hormones in our bodies, to drug treatments for allergies, COVID-19, and even cancer! We’ve already learned a bit...
Crash Course
Aldehyde and Ketone Reactions - Hydrates, Acetals, & Imines: Crash Course Organic Chemistry
We’ve already learned the basics of carbonyl chemistry and talked about how we can synthesize aldehydes and ketones, but there’s still so much more to learn, like the role carbonyl groups play in reactions involving sedatives! In this...
Professor Dave Explains
Reactions of Beta-Dicarbonyl Compounds
Looking at the usage of beta-dicarbonyl compounds.
Professor Dave Explains
The Haloform Reaction
Once again, we will be interested in learning about reactions that break carbon-carbon bonds, as this will allow us to perform necessary transformations on substrates. The haloform reaction is one such reaction, and it is commonly used...
Professor Dave Explains
Beckmann Rearrangement
Have you ever had a ketone and wished you had an amide instead? Not to worry! The Beckmann rearrangement is the solution to your problems. Check out this nifty reaction where we get an oxime and then get an alkyl group to migrate. We can...
Professor Dave Explains
Baeyer-Villiger Oxidation
We just learned how to make lactams out of cyclic ketones, is there a similar way that we can make lactones? There is! Try the Baeyer-Villiger oxidation. This is another one of those rearrangement type of reactions, only this time we are...
Catalyst University
NAD: Structure and Reduction of NAD to NADH
NAD: Structure and Reduction of NAD to NADH
Professor Dave Explains
Vilsmeier Reaction
What's a formylation? The introduction of a formyl group, of course. This refers to a way to make aldehydes. The Vilsmeier reaction is one such method, developed in 1927. Let's get a look at this reaction, its mechanism, and the...
Catalyst University
Weak C-O Bond Oxidations With PCC, DMP, etc.
Weak C-O Bond Oxidations With PCC, DMP, etc.
Professor Dave Explains
Aldol Condensation
Introducing aldol condensation and enolate chemistry in general.
Professor Dave Explains
Regioselective Enolization and Thermodynamic vs. Kinetic Control
Using regioselective enolization to introduce the concept of thermodynamic vs. kinetic control.
Professor Dave Explains
Fischer Indole Synthesis
We've talked about a few heterocycles, but one important aromatic one we didn't mention is the indole. This is a component of a variety of biomolecules. So how can we make them? Nobel prize winner Emil Fischer developed the Fischer...
Catalyst University
Schiff Base Chemistry 2 Monoamine Oxidase
Schiff Base Chemistry 2 Monoamine Oxidase
Professor Dave Explains
Passerini Reaction
What are isonitriles good for? The Passerini reaction! This is a very neat multi-component reaction that is good for generating chemical libraries. When was it invented? What's the mechanism? What are we doing with it today? Let's find out!
Catalyst University
Mixture of Reduction Practice Problems in OCHEM
Mixture of Reduction Practice Problems in OCHEM
Catalyst University
Carbohydrate Structure Aldohexoses and Ketohexoses
Carbohydrate Structure Aldohexoses and Ketohexoses
Professor Dave Explains
Mannich Reaction
One of the most important name reactions is the Mannich reaction, named after German chemist Carl Mannich, who developed it in 1912. In its original form, this takes formaldehyde, an enolizable ketone, and a secondary amine, and produces...
Professor Dave Explains
Oxidation of Alkenes Using Potassium Permanganate (Hot and Cold Conditions)
We've seen that KMnO4 can oxidize alcohols and aldehydes to give carboxylic acids and ketones, but this reagent can also oxidize alkenes. The product(s) will be different depending on whether we use cold basic conditions or hot acidic...
Catalyst University
Ketone Bodies | Catabolism of β-hydroxybutyrate, Acetoacetate, & Acetone
In this video, we will discuss the catabolic pathways for the three principle ketone bodies: β-hydroxybutyrate, Acetoacetate, & Acetone