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\nFischer Indole Synthesis\n

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\n\nPublisher:\n\nProfessor Dave Explains\n\n\n
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\nWe've talked about a few heterocycles, but one important aromatic one we didn't mention is the indole. This is a component of a variety of biomolecules. So how can we make them? Nobel prize winner Emil Fischer developed the Fischer...\nWe've talked about a few heterocycles, but one important aromatic one we didn't mention is the indole. This is a component of a variety of biomolecules. So how can we make them? Nobel prize winner Emil Fischer developed the Fischer indole synthesis in 1882 to do precisely this, using aryl hydrazines and ketones. What's the mechanism? Is that a sigmatropic shift you spot in there? Yes it is! It's a fun one, check it out.\n
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Resource Details

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Media Length
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7:14
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Grade
9th - Higher Ed
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Subjects
Science
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Media Type
Instructional Videos
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Source:
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\nProfessor Dave Explains\n\n
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Date
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2021
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Language
English
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Audiences
For Teacher Use
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Fine Print: Educational Use
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Concepts

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ketones, nitrogen, series, nature, water
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Additional Tags

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fischer indole synthesis, heterocycles, indoles, emil fischer, hydrazone, sigmatropic shift, enolization, c6 substitution, arrow hydrazine, major product, fisher synthesis, ketone involving, membered ring, product, synthesis, ketone, ring, mechanism, yield, involved, side, reaction, complex, carbons, substituent, case, earlier, talked, indole, acetone, elimination, aryl hydrazine
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