Paquime, Casas Grandes, which reached its apogee in the 14th and 15th centuries, played a key role in trade and cultural contacts between the Pueblo culture of the south-western United States and northern Mexico and the more advanced civilizations of Mesoamerica. The extensive remains, only part of which have been excavated, are clear evidence of the vitality of a culture which was perfectly adapted to its physical and economic environment, but which suddenly vanished at the time of the Spanish Conquest.