If you are looking for a great way to present natural selection in humans, look no further. This handout is intended to accompany the 14-minute video The Making of the Fittest: Natural Selection in Humans, which can be found on the publisher's website. Before watching the video, learners read a page of information about sickle cell disease, then answer questions about sickle cell disease, and about the progress of science as a social process. Next, the video is shown, with pupils answering several higher-level thinking questions about concepts presented in the video.