Curated OER
Determining Cutting Site Locations
Students explore DNA restriction mapping. They cut pieces of paper into lengths representing those produced when specific enzymes are used to cut a strand of DNA.
Curated OER
Using a Controlled Experiment to Identify Two Unknown Plasmids
Student demonstrate knowledge of recombinant DNA techniques (restriction enzyme digest, gel electrophoresis, and staining gel). They demonstrate skills needed to complete a gel electrophoresis and interpret a stained gel. Pupils solve...
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Biotechnology
The concepts here cover the gamut of biotechnological engineering. Information is given about plasmids and genetic manipulation. After reviewing genetic engineering, this slide show would be useful to recap some of the main procedures.
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Biotechnology
The metaphors used here to describe the "cut and paste" procedures for genetic engineering will really help your biologists in their understanding of restriction enzymes and DNA. The uses of genes that are isolated and incorporated into...
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Gene Cloning Worksheet #1
In this gene cloning worksheet, high schoolers are given a gene sequence of DNA, plasmid DNA, 3 restriction enzymes, their cut patterns and a DNA ligase. They answer 6 questions about the results of using different restriction enzymes to...
Curated OER
Who Ate The Cheese?!
In this crime scene investigation worksheet, students simulate DNA sequencing and DNA restriction analysis using paper strips of DNA. Students compare the crime scene DNA to the suspects and determine who is guilty.
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Genetic Technology
In this genetic worksheet, students will match 6 terms associated with gene engineering to their correct definition. Then students will complete a table indicating if the vector is mechanical or biological. Finally, students will...
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Science Lesson: Chocolate Flavored Cherries
High schoolers are able to identify start and stop sequences in DNA. They are able to model using restriction enzyme and ligase to remove sections of DNA and reattach them. Students are introduced to the process of recombinat DNA...
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Simulation of Gene Splicing
Students use the exercise as a prelude to a "wet" lab or as a substitute for such a lab. It correlates well with colony transformation labs. This lab is recommended for students what have difficulty with the abstractions that genetic...
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Science: Designer genes
Students engineer new organisms using biotechnology. In small groups, they write procedures, list benefits and drawbacks, and explain how their new organism might affect the environment. After creating their new organisms, they present...
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DNA Race Track
Twelfth graders simulate a DNA fragment running through a gel electrophoresis in a class activity. Students work in teams as a DNA sample with each person on the team representing a fragment that moves through the gel at a specific speed.
Curated OER
DNA Fingerprinting through a Chemistry Lens
Students explore DNA and restriction enzymes using fragments of DNA separated by electrophoresis on an agarose gel. They analyze the results to see "whodunit".