Remember the Ice Bucket Challenge craze this summer? Meet the mom who started it all. When Nancy Frates's son Pete hurt his wrist in a baseball game, he got an unexpected diagnosis: it wasn’t a broken bone, it was ALS, and there is no...

Lou Gehrig and Bill Russell exemplified character in sports through their humility, leadership, and dedication to their teams and communities. Gehrig, a legendary first baseman for the Yankees, was a quiet, team-first player known for...

In this video, we explore the basic biochemical mechanism of neuronal death in amyotrophic lateral sclerosis or ALS.

In this video, we explore the basic clinical presentation of amyotrophic lateral sclerosis or ALS. In the next video, we will take a look at the specific biochemical mechanism that kills neurons in ALS.

Let's Donate to ALS Research | Most EXTREME Ice Bucket Challenge

The executive director of 161st Business Improvement District says the BID wants to breathe life into Lou Gehrig's Plaza.

Crowded exterior of the Baseball Hall of Fame in Cooperstown where baseball manager Casey Stengel is being inducted in Hall of Fame / CU wall plaque reading: 'COOPERSTOWN BIRTHPLACE OF BASEBALL' / people walk around the interior of the...

B/W 1939 Lou Gehrig standing solemnly in center of crowded stadium / farewell speech

Lou Gehrig smiles and stands with New York Yankees Manager Joe McCarthy then goes on to bat and run the bases in Yankee Stadium.

B/W 1930s Yankees manager, Joe McCarthy shaking hands with Lou Gehrig / other players in background

B/W 1939 solemn Lou Gehrig chewing gum + looking down then looking up in crowded stadium / farewell

B/W 1930s slow motion REAR VIEW Lou Gehrig batting

Title card: "60,000 turn out to see Yanks beat Giants 7-3 in game sponsored by the Acting Mayor, Mr. McKee" / New York City acting mayor Joseph V McKee in stands throws out ball during charity game to benefit the Mayor's unemployment...

Title card: "Baseball - Old-Timers' Day at Yankee Stadium" / WS players on field and crowd in stands / crowd in stands / old-timers in dugout posing for photo opportunity / group of photographers and cameramen taking pictures / pan...

Title card: "Champions of the World," fade in baseball game / crowd in stands at the Polo Grounds / Yankees manager Joe McCarthy shaking hands with owner Jacob Ruppert / CU player at bat maybe Giant Harry Danning; he hits and runs /...

Countdown / Sportfolio intro sequence / card: "Insert commercial here" / Yankees manager Joe McCarthy shaking hands with Yankees owner Jacob Ruppert in dugout as they pose for photo opportunity / close shot of Yankees player Myril Hoag...

Title card: "All-Star Baseball" superimposed over WS Cleveland Stadium / WS stands filled with spectators / National League players in dugout / CU players in dugout / WS American League players / MS Lou Gehrig, Joe Cronin, Jimmy Foxx, Al...

Countdown / Sportfolio intro sequence / card: "Place commercial here" / High angle men huddled at home plate, stands in bkgd / High angle, deep shot hawkers walk amongst seated spectators / CU two baseball players shake hands / VS # 3...

New York Yankee Lou Gehrig delivers his retirement speech.

INTERVIEW: Richard Schiff and Sheila Kelley on attending the event, how their lives were touched by ALS, why ALS is such a devasting illness, the Lou Gerhig legacy at the 6th Annual Project ALS Los Angeles Benefit at Paramount Studios in...

First ever Major League Baseball All-Star game at Comiskey Park / This historic game occurred during the height of the Great Depression and featured the first home run hit in an All-Star game performed by baseball legend Babe Ruth.

B/W 1939 PROFILE solemn Lou Gehrig making farewell speech in crowded stadium

Lou Gehrig, dressed as cowboy, on horse / Babe Ruth hits homerun, rounds first base, rounds third and to home / 1927 banner going up pole / pan 1927 Yankee team / CU Bob Meusel, Tony Lazzeri, Herb Pennock / VS Lefty Gomes pitching / CU...

Title card: "Japan goes big for Babe, Tokyo - Fans turn out by thousands to welcome US baseball stars led by Ruth! Series with native champs 'biggest news' in Empire" / fans on dock waving flags as 'Empress of Japan' docks / Ruth and...