{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-572d6a42.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-f4d0de30.css\" media=\"all\" /\u003e\n\u003cdiv data-title='Vaccine research offers fresh hope against Ebola' data-url='/boclips/videos/6878cbc4860c8396ee54ce25' data-video-url='/boclips/videos/6878cbc4860c8396ee54ce25' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nVaccine research offers fresh hope against Ebola\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eIt is nearly five years since the Ebola virus outbreak in Sierra Leone which also hit the neighbouring West African countries of Liberia and Guinea. At least 11,300 people died and some 28,000 were infected by the virus between December...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eIt is nearly five years since the Ebola virus outbreak in Sierra Leone which also hit the neighbouring West African countries of Liberia and Guinea. At least 11,300 people died and some 28,000 were infected by the virus between December 2013 and May 2016. The unprecedented health crisis sparked an equally unprecedented research effort to fight the deadly disease, particularly in the search for a safe and effective vaccine.  \u003cbr/\u003eBack in 2014 Emma was 23-years-old. She was studying Management in Freetown, the country's capital. She knew that a deadly virus transmitted through body fluids was causing a lot of suffering. And then one day she came down with a high fever, diarrhoea, violent vomiting and joint pain.  \u003cbr/\u003e\u003cbr/\u003e\"My friend lost her father. And I visited her. I was there for three days. The father died. They buried him. And I was still in the house. After they buried him I was back where I stayed. And I started to feel fever. I was feeling so hopeless at that time. The disease was attacking me. I was afraid. Because they said, ''Whenever they take you to the treatment centre you will not come back again.\" So I started to lock myself inside the room.'' \u003cbr/\u003e\u003cbr/\u003e\u003cbr/\u003eEmma was isolated for six days at home, and then taken to a local clinic. She eventually won her battle against Ebola, but it came at a cost. Forced to stop her studies, she now lives at home with few prospects of finding a job.  \u003cbr/\u003e\u003cbr/\u003eThe region where Emma lives was heavily affected by the outbreak. Whole villages were placed under quarantine. Families were not able to meet for fear of contagion and the local economy collapsed.  \u003cbr/\u003eThe scale of the outbreak is one of the reasons why the area was selected by scientists from a European research project. They are trying to develop a new vaccine regime to prevent the disease. More than 1000 healthy volunteers are taking part in the clinical trial in Sierra Leone. It includes adults and children between the ages of one and 17.   \u003cbr/\u003e\u003cbr/\u003eIsha Kanawah is a nurse at Ebovac-Salone, at University of Sierra Leone.  \u003cbr/\u003e\u003cbr/\u003e\u003cbr/\u003e\"If my child takes the vaccine, is my child going to be cured for Ebola? They (the parents) ask this question. And we tell them: ´this is a vaccine trial, so we don´t know yet if it might cure your child from having Ebola. This is a study,´\" she says.   \u003cbr/\u003e\u003cbr/\u003eAll the volunteers are closely monitored before and after their injection. Doctors routinely inform volunteers and their families about the disease they are trying to prevent. \u003cbr/\u003e\u003cbr/\u003e\"Ebola is one of the many viral haemorraghic fevers. Precisely, it is a multi-system disease, meaning that it can affect almost any organ  in your body. It can affect your eyes, your ears, your blood vessels, your skin... almost everything, also the reproductive system,\" says Michael Morlai Kamara, a doctor at  Ebovac -Salone, University of Sierra Leone. \u003cbr/\u003e\u003cbr/\u003eAccording to the World Health Organisation (WHO), Ebola's mortality rate ranges from 50 percent to 90 percent.  \u003cbr/\u003e\u003cbr/\u003e\u003cbr/\u003eMany doctors, like Agnes Bangura, who are now involved in the clinical trial, were on the frontline during the last major outbreak.  \u003cbr/\u003e\u003cbr/\u003e\"No one was safe. That was what actually motivated me to take up this job. To see that we are going to work on this vaccine to prevent these things from happening again.\"  \u003cbr/\u003e\u003cbr/\u003e\u003cbr/\u003eShe says the new candidate vaccine is showing encouraging signs. \u003cbr/\u003e\"We've seen that the vaccine is safe. And participants are actually producing antibodies in their blood against the virus. So it is very promising.\"  \u003cbr/\u003e\u003cbr/\u003eThe volunteers blood samples are analysed in local laboratories, many of which did not exist before the outbreak. The region is still not even connected to the national grid, so researchers rely on generators to power their high-tech equipment.  \u003cbr/\u003e\u003cbr/\u003e\u003cbr/\u003eKen Awuondo, a Biomedical Scientist from the London School of Hygiene \u0026 Tropical Medicine, says: \"We are looking at the safety of the subject (volunteer); if the vaccine is safe to be given to the subject. Secondly, we are looking at the efficacy; if the vaccine has efficacy that is able to work and prevent the disease. And thirdly, we are looking at the immunogenecity; can it mount the immune system, can it provoke the body's immune system, so the body can fight the disease, the viruses, and especially in our case Ebola.\"  \u003cbr/\u003e\u003cbr/\u003eThe vaccine regime, under trial in Sierra Leone, is being developed and closely monitored from Leiden in the Netherlands. The regime is made up of two separate vaccines. Researchers say that dual approach has the potential to provide a better and more long lasting immunity against a dangerous family of viruses.  \u003cbr/\u003eJohan Van Hoof, is the Managing Director of Janssen Vaccines \u0026 Prevention B.V. \u003cbr/\u003e\u003cbr/\u003e\u003cbr/\u003e\"When you get infected, the virus really reproduces very rapidly. You have millions and millions of viruses in your blood. And that leads to very high mortality. And that also implies that the immune protection that you need to get with a vaccine needs to be extremely high to be able to cope with such a load of virus. Ebola is not gone. 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