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\nMHC Class I and Class II Structure: Function and Difference\n

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\nThe Major Histocompatibility Complex (MHC) is a tightly linked gene cluster encoding cell surface molecules essential for antigen presentation and tissue graft rejection, known as histocompatibility antigens. In humans (HLA complex on...\nThe Major Histocompatibility Complex (MHC) is a tightly linked gene cluster encoding cell surface molecules essential for antigen presentation and tissue graft rejection, known as histocompatibility antigens. In humans (HLA complex on chromosome 6), MHC molecules are classified into Class I and Class II: Class I molecules present peptides (8–10 amino acids) to CD8+ T cells, while Class II molecules have an open peptide-binding cleft and present antigens to CD4+ T cells. Structurally, Class I consists of a 45kDa α-chain and β2-microglobulin, while Class II comprises α and β chains that interact non-covalently to display longer peptides.\n
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Resource Details

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Educator Rating
Not yet Rated
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Media Length
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6:56
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Grade
9th - Higher Ed
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Subjects
Science
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Media Type
Instructional Videos
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Source:
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\nBioMagica\n\n
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Date
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2018
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Language
English
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Audiences
For Teacher Use
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Fine Print: Educational Use
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Concepts

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domain, cells, molecules, genes, segments
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Additional Tags

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csir, net, mhc, class i, class ii, set, major histocompatibilty complex, alpha chain, transmembrane segment, binding site, mhc class, cell surface, cell membrane, a3 domain, cd8t cells, mhc molecules, beta chain, cell, peptide, interaction, beta 2, beta, antigen, structure, video, study, expressed, present, focus, case, respective, consists
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\n\" data-title=\"Get Full Access\" data-container=\"body\" rel=\"popover\" tabindex=\"0\" aria-label=\"Play video: MHC Class I and Class II Structure: Function and Difference\" href=\"/subscription/new\">\"MHC\n\n
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