{"page":"\n\n
\n
\n
\n
\n
\n\nVideo\n
\n

\nZinc Finger Nucelases\n

\n
\n
\nGet Free Access for 10 Days!\n
\n
\n
\n
\n
\n
×
\n\n\n
\n\nPublisher:\n\nCurated Video\n\n\n
\n
\nZinc Finger Nucleases (ZFNs) are engineered molecular tools composed of a zinc finger DNA-binding domain fused to a FokI DNA-cleavage domain, allowing precise targeting and cutting of specific DNA sequences. Once the DNA is cut, natural...\nZinc Finger Nucleases (ZFNs) are engineered molecular tools composed of a zinc finger DNA-binding domain fused to a FokI DNA-cleavage domain, allowing precise targeting and cutting of specific DNA sequences. Once the DNA is cut, natural repair mechanisms such as non-homologous end joining (NHEJ) or homology-directed repair (HDR) can be harnessed for gene editing, making ZFNs valuable in both research and therapeutic applications. Despite their specificity, challenges like off-target effects and potential for genomic instability remain, though advancements such as increasing zinc finger count help reduce these risks.\n
\n
\n\n
\n
\n
\n
\n

Resource Details

\n
\n
\n
\n
Curator Rating
\n
\n
\n
\n
\n
\n
Educator Rating
Not yet Rated
\n
\n
\n
\n
\n
Media Length
\n
4:51
\n
\n
\n
\n
\n
Grade
9th - Higher Ed
\n
\n
\n
\n
\n
Subjects
Science
6 more...
\n
\n
\n
\n
\n
Media Type
Instructional Videos
\n
\n
\n
\n
\n
Source:
\n
\nBioMagica\n\n
\n
\n
\n
\n
\n
Date
\n
2019
\n
\n
\n
\n
\n\n
Language
English
\n
\n
\n
\n
\n
Audiences
For Teacher Use
2 more...
\n
\n
\n
\n
\n
Usage Permissions
Fine Print: Educational Use
\n
\n
\n
\n
\n
\n

Additional Materials

\n
\n\nSign in or Join Now
\" data-title=\"Get Full Access\" data-container=\"body\" rel=\"popover\" tabindex=\"0\" href=\"/subscription/new\">Video Transcript\n
\n
\n\nSign in or Join Now
\" data-title=\"Get Full Access\" data-container=\"body\" rel=\"popover\" tabindex=\"0\" href=\"/subscription/new\">Video Preview\n
\n
\n
\n

Concepts

\n
\n
gene therapy, genetics, biotechnology, species, nucleotides
\n
\n\n\n
\n
\n
\n
\n

Additional Tags

\n
\n
csir, net, zinc finger nucelases, talens, artificial restriction enzyme, genome editing tool, gate, life sciences, genome editing nucleases, zfn vs talens, amino acid, cleavage domain, dimerized form, genome editing, target site, target, genome, gene, talons, site, endonuclease, binding, make, insert, recognize, specificity, attached, bind, enzyme, fork, half, create, leading, cons
\n
\n\n\n
\n
\n
\n
\n

Classroom Considerations

\n
Video is ad-free
\n
\n
\n

Educator Ratings

\n
\n
\n
\n
\n
\n\nShow resource details\n
\n
\n\" data-title=\"Get Full Access\" data-container=\"body\" rel=\"popover\" tabindex=\"0\" aria-label=\"Play video: Zinc Finger Nucelases\" href=\"/subscription/new\">\"Zinc\n\n
\n
\n
\n\n\n\n"}