{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='The Complement System Song: How The Complement System Works' data-url='/boclips/videos/671e8a3347d7883d17f37e6f' data-video-url='/boclips/videos/671e8a3347d7883d17f37e6f' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nThe Complement System Song: How The Complement System Works\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003e Do you know complex our complement system is? Check out \"The Complement System Song\"This song goes over the entire process from the complement system being made up of proteins that are mostly produced in the liver to helping antibodies...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003e Do you know complex our complement system is? Check out \"The Complement System Song\"\u003cbr/\u003eThis song goes over the entire process from the complement system being made up of proteins that are mostly produced in the liver to helping antibodies and phagocytic cells remove microbes and damaged cells from the body. This song has it all! Don't forget to sing along :)\u003cbr/\u003e\u003cbr/\u003eCHORUS:\u003cbr/\u003eDo you know about the Complement System\u003cbr/\u003eThese proteins in the blood are on the scene\u003cbr/\u003eFrom C1 to 9, in defense they align\u003cbr/\u003eA cascade of events like a machine\u003cbr/\u003e\u003cbr/\u003eVERSE 1:\u003cbr/\u003eWhen the antibodies recognize the pathogen\u003cbr/\u003eC1 is activated in this race\u003cbr/\u003eC2 and 4 then split, and their parts take their place\u003cbr/\u003eTo form C3 converts\u003cbr/\u003eC3 convertase breaks down C3 into two parts\u003cbr/\u003eInto C3a and C3b\u003cbr/\u003eC3a attracts, C3b attacks\u003cbr/\u003eBy tagging for damage as you’ll see\u003cbr/\u003e\u003cbr/\u003eVERSE 2:\u003cbr/\u003eC3a is like a chemical attractant\u003cbr/\u003eThat brings in the phagocytes\u003cbr/\u003eThe phagocytes then eat the germs they meet\u003cbr/\u003eTrying to make everything alright\u003cbr/\u003eWhen C3b attaches to the pathogen\u003cbr/\u003eIt’s tagging it for destruction\u003cbr/\u003eBut that’s not all it’ll do, it makes C5 split in two\u003cbr/\u003eC5a and b will do do what they do\u003cbr/\u003e\u003cbr/\u003eVERSE 3:\u003cbr/\u003eC5b will join with C6 through 9\u003cbr/\u003eTo form the membrane attack complex\u003cbr/\u003eIt then sticks to the membrane of the pathogen\u003cbr/\u003eAnd I can’t wait to tell you what comes next\u003cbr/\u003eThis makes a hole in the membrane\u003cbr/\u003eThat allows for water to rush in\u003cbr/\u003eThe pathogen breaks a part, it’s what we wanted from the start\u003cbr/\u003eThanks to the complement system\u003cbr/\u003e\u003cbr/\u003eBRIDGE\u003cbr/\u003eBut there’s an alternate pathway that skips steps and starts with C-3\u003cbr/\u003eIt binds directly to the pathogen and interacts with factors P, B, and D\u003cbr/\u003eC3 then splits into C3a and b and the rest continues as we like to see\u003cbr/\u003eAnd that was the complement system, that helps defend you and me. 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