{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='Why do you gain weight with antidepressants and mood stabilizers?' data-url='/boclips/videos/65112e8760795c4682b86583' data-video-url='/boclips/videos/65112e8760795c4682b86583' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nWhy do you gain weight with antidepressants and mood stabilizers?\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eWhy do you gain weight with antidepressants and mood stabilizers?  In this video I discuss two way. One way is by blocking histamine 1 receptors. We usually think of histamine as something that is associated with allergies and your...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eWhy do you gain weight with antidepressants and mood stabilizers?\u003cbr/\u003e \u003cbr/\u003e In this video I discuss two way. One way is by blocking histamine 1 receptors. We usually think of histamine as something that is associated with allergies and your immune response. If you’re exposed to something your body is sensitive to, you get a histamine response that can look like itching, runny nose or even shortness of breath. And if you take an antihistamine like Benadryl, it slows the allergic reaction and you feel better. That's how it works from the neck down. Histamine acts differently in your brain. In certain parts of your brain, it’s responsible for wakefulness or your ability to be alert. That's why if you take an anti-histamine it may reduce your allergic reaction, but if it crosses the blood brain barrier, it can also make you sleepy because it's blocking histamine’s stimulating effect in your brain. There are four histamine receptors, I’m going to talk about H1 receptors.\u003cbr/\u003e A second mechanism is blocking the 5HT 2c receptors. This is just a type of serotonin receptor. It’s been shown in mice that if you activate their 5HT2c receptors, they lose weight because they eat less. And if you block the receptor they became obese. Many of the newer antipsychotic medications block this receptor. Of all the antipsychotic medications, the worst offenders when it comes to weight gain are olanzapine, clozapine and quetiapine. And all three of these medications block 5HT2c.\u003cbr/\u003e \u003cbr/\u003e\u003cbr/\u003e References\u003cbr/\u003e He M, Deng C, Huang XF. The role of hypothalamic H1 receptor antagonism in antipsychotic-induced weight gain. CNS Drugs. 2013;27(6):423–434. \u003cbr/\u003e \u003cbr/\u003e Nikhil Nihalani, Thomas L. Schwartz, Umar A. Siddiqui, and James L. Megna, “Weight Gain, Obesity, and Psychotropic Prescribing,” Journal of Obesity, vol. 2011, Article ID 893629, 9 pages, 2011\u003cbr/\u003e \u003cbr/\u003e Halford JC1, Harrold JA. 5-HT(2C) Receptor agonists and the control of appetite. Handbook Exp Pharmacol. 2012;(209):349-56. \u003cbr/\u003e \u003cbr/\u003e Dayabandara M, Hanwella R, Ratnatunga S, Seneviratne S, Suraweera C, de Silva VA. Antipsychotic-associated weight gain: management strategies and impact on treatment adherence. Neuropsychiatr Dis Treat. 2017;13:2231–2241. \u003cbr/\u003e \u003cbr/\u003e Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. 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