{"page":"\n\n
\n
\n
\n
\n
\n\nVideo\n
\n

\nWhy Do Antidepressants Take So Long To Work?\n

\n
\n
\nGet Free Access for 10 Days!\n
\n
\n
\n
\n
\n
×
\n\n\n
\n\nPublisher:\n\nCurated Video\n\n\n
\n
\nAntidepressants can take anywhere from 2 -6 weeks to see a therapeutic effect. You may notice a little improvement sooner than that, but the usual is weeks. There's a couple reasons for this. The first is due to the way the drug works....\nAntidepressants can take anywhere from 2 -6 weeks to see a therapeutic effect. You may notice a little improvement sooner than that, but the usual is weeks.

There's a couple reasons for this. The first is due to the way the drug works. Medications have to reach a steady state in your body before you can get a reliable effect. It takes approximately 5 half-lives to reach steady state. If you have a medication that has a half-life of 24 hours, it takes five days to reach steady state.

A second reason has to do with the delayed effect the increase in serotonin has on your thoughts. You have the increased serotonin, then a delay, then you have the downstream neuroadaptive effects which is reducing and increasing various receptors, then you have a change in mood that causes a change in emotional bias.

A cognitive model of depression is that negative thinking both causes and perpetuates depression. When you're depressed, you have more negative view of the world. Depression affects what you pay attention to. You're more likely to notice negative facial expressions, spot negative cues in your environment and draw negative conclusions about things. This is referred to as a negative bias or negative valence.

Thoughts, feelings and behaviors are all connected. There's still a model for endogenous depression where you develop depression soley based on brain changes. But we be still believe even that depression affects your thinking. It's debatable as to which came first, depression illness or thought depressed thoughts. But the mind and the body are one. And the best approach to depression is to address them both equally. The mind approach would be through therapy or self-help measures to address your mindset and the body approach would be diet, exercise, sleep hygiene and medication if appropriate.

References
Wilson SJ, Bell C, Coupland NJ, Nutt DJ. Sleep changes during long-term treatment of depression with fluvoxamine – a home-based study. Psychopharmacology 2000; 149: 360–5.

Harmer CJ, O'Sullivan U, Favaron E, Massey-Chase R, Ayres R, Reinecke A, Goodwin GM, Cowen PJ. Effect of acute antidepressant administration on negative affective bias in depressed patients. Am J Psychiatry. 2009 Oct;166(10):1178-84. doi: 10.1176/appi.ajp.2009.09020149. Epub 2009 Sep 15. PMID: 19755572.

Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.\n
\n
\n\n
\n
\n
\n
\n

Resource Details

\n
\n
\n
\n
Curator Rating
\n
\n
\n
\n
\n
\n
Educator Rating
Not yet Rated
\n
\n
\n
\n
\n
Media Length
\n
7:55
\n
\n
\n
\n
\n
Grade
Higher Ed
\n
\n
\n
\n
\n
Subjects
Career & Technical Education
1 more...
\n
\n
\n
\n
\n
Media Type
Instructional Videos
\n
\n
\n
\n
\n
Source:
\n
\nDr. Tracey Marks\n\n
\n
\n
\n
\n
\n
Date
\n
2021
\n
\n
\n
\n
\n\n
Language
English
\n
\n
\n
\n
\n
Audiences
For Teacher Use
2 more...
\n
\n
\n
\n
\n
Usage Permissions
Fine Print: Educational Use
\n
\n
\n
\n
\n
\n

Additional Materials

\n
\n\nSign in or Join Now
\" data-title=\"Get Full Access\" data-container=\"body\" rel=\"popover\" tabindex=\"0\" href=\"/subscription/new\">Video Transcript\n
\n
\n\nSign in or Join Now
\" data-title=\"Get Full Access\" data-container=\"body\" rel=\"popover\" tabindex=\"0\" href=\"/subscription/new\">Video Preview\n
\n
\n
\n

Concepts

\n
\n
nerves, depression, weeks, sleep, mental health
\n
\n\n\n
\n
\n
\n
\n

Additional Tags

\n
\n
medikamente gegen depressionen und angstzustände, psychische gesundheit, antidepressants, depression medication, dr tracey marks, lexapro, medicación para la depresión y la ansiedad, medication for depression and anxiety, mental health channel, mental health education, médicaments pour la dépression et l'anxiété, salud mental, santé mentale, الصحة النفسية, دواء للاكتئاب والقلق, अवसाद और चिंता के लिए दवा, मानसिक स्वास्थ्य, emotional bias, negative views, pay attention, negative thinking, increased serotonin, domino effect, depression affects, serotonin, body, antidepressant, nerve, happen, mind, address, medication, thoughts, notice, medications, hour, increase, result, delay, change, world
\n
\n\n\n
\n
\n
\n
\n

Classroom Considerations

\n
Best For: Explaining a topic
Video is ad-free
\n
\n
\n

Educator Ratings

\n
\n
\n
\n
\n
\n\nShow resource details\n
\n
\n\" data-title=\"Get Full Access\" data-container=\"body\" rel=\"popover\" tabindex=\"0\" aria-label=\"Play video: Why Do Antidepressants Take So Long To Work?\" href=\"/subscription/new\">\"Why\n\n
\n
\n
\n\n\n\n"}