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Pyruvate Kinase Deficiency is the most common red blood cell (RBC) enzyme defect that leads to hemolytic anemia. Decreased levels and activity of the...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eLesson on Pyruvate Kinase Deficiency Disorder: Symptoms, Pathophysiology and Treatment. Pyruvate Kinase Deficiency is the most common red blood cell (RBC) enzyme defect that leads to hemolytic anemia. 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