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\nMacroautophagy | Regulation During Feeding, Fasting and Starvation\n

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\n\nPublisher:\n\nJJ Medicine\n\n\n
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\nLesson on macroautophagy and regulation by fasting and starvation, with an additional detailed overview of how macroautophagy is inhibited during feeding and the fed state. Macroautophagy is a nutrient responsive process and is inhibited...\nLesson on macroautophagy and regulation by fasting and starvation, with an additional detailed overview of how macroautophagy is inhibited during feeding and the fed state. Macroautophagy is a nutrient responsive process and is inhibited during feeding and the fed state when nutrient and energy levels are high. During short-term fasting, macroautophagy becomes activated by AMPK, and inhibition of mTOR leads to further activation of macroautophagy and activation of transcription factor EB (TFEB), which is the master regulator of lysosomal biogenesis and autophagy. Hey everyone. Here is another lesson on macroautophagy. This is a continuation of the \"Autophagy: Introduction to Macroautophagy\" lesson, and further elaborates on how macroautophagy is regulated, in particular by nutrient status of the cell including the fed state, and fasting and starvation. We also briefly introduce the idea of a chronological differentiated activation during fasting of different proteolytic systems with acute activation of the ubiquitin proteasome system, macroautophagy activation within 4 hours of fasting and chaperone-mediated autophagy activation within 12 hours of fasting. We will discuss this topic further in a future lesson.\n
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Resource Details

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Curator Rating
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Educator Rating
Not yet Rated
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Media Length
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11:48
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Grade
Higher Ed
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Subjects
Science
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Media Type
Instructional Videos
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Source:
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\nJJ Medicine\n\n
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Date
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2018
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Language
English
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Audiences
For Teacher Use
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Usage Permissions
Fine Print: Educational Use
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Concepts

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starvation
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Additional Tags

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macroautophagy, autophagy and fasting, macroautophagy and fasting, macroautophagy pathway, macroautophagy process, macroautophagy and feeding, macroautophagy and fed state, macroautophagy and starvation, macroautophagy activation, macroautophagy regulation, autophagy regulation, regulation of macroautophagy, macroautophagy animation, autophagy pathway, how to increase autophagy, how to increase macroautophagy, autophagy fasting, fasting autophagy, macro topology, fed state, transcriptional repressors, phosphate group, negative regulator, clear sequence, clear network, ppar alpha, auto lysosomes, mtor complex, activates oak, prohibits tvdb, macroautophagy function, complex, activates, process, proteins, activation, important, autophagy, calcineurin, autophagosomes, occurs, autophagosome, inhibit, processes, junk, lesson
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Classroom Considerations

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Best For: Explaining a topic
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\n\" data-title=\"Get Full Access\" data-container=\"body\" rel=\"popover\" tabindex=\"0\" aria-label=\"Play video: Macroautophagy | Regulation During Feeding, Fasting and Starvation\" href=\"/subscription/new\">\"Macroautophagy\n\n
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