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\nWnt/β-Catenin Signaling Pathway | Overview, Purpose and APC Mutations\n

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\n\nPublisher:\n\nJJ Medicine\n\n\n
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\nLesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory factors, β-Catenin regulation and role of the pathway in growth,...\nLesson on the Wnt/β-Catenin signaling pathway (also known as simply the Wnt signaling pathway), including an introduction to the pathway, Wnt growth stimulatory factors, β-Catenin regulation and role of the pathway in growth, proliferation and development. Wnt proteins act as The Wnt signaling pathway is critically important in embryonic development, particularly in the development of the heart. As such the Wnt/β-Catenin signaling pathway is highly conserved. However, if mutations occur in proteins in the pathway, such as mutations in the adenomatous polyposis coli (APC) gene, this can lead to inappropriate activation of the Wnt/β-Catenin signaling pathway.

NOTE: In the video, I misspoke and said that Beta catenin enters the \"mitochondria\" - I meant to say it enters the nucleus. Sorry about the confusion everyone. Hope you find the video helpful :)

Hey everyone, here is another biomedical lesson, and this one is on the canonical Wnt signaling pathway. In this lesson, you will be introduced to the Wnt signaling pathway, and the purpose of the Wnt pathway. You will also learn the signaling pathway in a step-by-step fashion, starting with how the Wnt/β-Catenin signaling pathway is regulated during inactivation, how cellular beta catenin levels are regulated by the destruction complex, and how the pathway can become activated by the extracellular signaling Wnt proteins, which are growth stimulatory factors. Finally, you will learn what happens when the APC protein in the destruction complex is mutated, leading to inappropriate activation of the Wnt signaling pathway.\n
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Resource Details

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Media Length
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6:31
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Grade
Higher Ed
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Subjects
Science
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Media Type
Instructional Videos
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Source:
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\nJJ Medicine\n\n
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Date
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2017
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Language
English
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Audiences
For Teacher Use
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Fine Print: Educational Use
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cancer, leads
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wnt signaling pathway, wnt pathway, wnt beta catenin signaling pathway, beta catenin signaling pathway, wnt signalling pathway, β-catenin signaling pathway, wnt/β-catenin signaling pathway, wnt and beta catenin, catenin signaling pathway, wnt and catenin, wnt signaling pathway and cancer, β-catenin signaling pathway and cancer, wnt beta catenin apc, wnt apc, β-catenin apc, beta catenin apc, wnt pathway cancer, beta catenin pathway cancer, wnt signaling pathway animation, beta trcp, beta cat, proteasomal degradation, beta catenin, critically important, target genes, destruction complex, receptor frizzled, apc mutation, inactivated state, embryonic development, activated state, complex, proteins, inactivated, levels, development, activated, pathway, talk, problems, occur, lead, transported, exosomes, body, mutations, bound
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