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\nNon-Canonical NF-kB Signaling Pathway | Mechanism and Function\n

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\n\nPublisher:\n\nJJ Medicine\n\n\n
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\nLesson on the Non-Canonical NF-kB Signaling pathway. The Noncanonical NFkB signaling pathway is primarily involved in B cell maturation, lymphoid organogenesis and immune system functioning. This signaling pathway differs from the...\nLesson on the Non-Canonical NF-kB Signaling pathway.
The Noncanonical NFkB signaling pathway is primarily involved in B cell maturation, lymphoid organogenesis and immune system functioning. This signaling pathway differs from the canonical pathway in terms of cell receptors and cytosolic adaptor proteins. In a constitutional, inactivated state, cell levels of NIK are kept low due to proteasomal degradation. However, when this pathway becomes activated, NIK levels rise, leading to activation of IKKalpha and subsequent formation of an active protein dimer. This active protein dimer translocates into the nucleus and leads to the induction of non-canonical NF-kB signaling genes, which increase B cell survival. Unsurprisingly, mutations in this pathway can lead to the onset of specific immune cancers including Hodgkin’s lymphoma and diffuse large B cell lymphoma.\n
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Media Length
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9:28
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Grade
Higher Ed
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Subjects
Science
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Media Type
Instructional Videos
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\nJJ Medicine\n\n
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Date
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2018
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Language
English
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For Teacher Use
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Fine Print: Educational Use
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non-canonical nf-kb, non-canonical nf-kb signaling pathway, noncanonical nf-kb signaling pathway, nf-kb signaling pathway, nfkb signaling pathway, nfkb signaling, nf-kb signaling, non canonical nf-kb signaling, non-canonical nf-kb signaling, nf-kb signaling lesson, introduction to nf-kb signaling, overview of nf-kb signaling, nf kb animation, nf kb signaling pathway, nf kb pathway, nfkb animation, noncanonical nfkb activation, nf kb pathway explained, nf kb pathway animation, ik alpha, lymphoid organogenesis, bcl xl, nik protein, inducing kinase, tnf receptor, cell maturation, nf kappa, signaling pathway, canonical pathway, active dimer, receptor, canonical, cell, active, kappa, pathway, form, involved, dimer, siap, ligands, increased, degradation, function, lesson, video, activated, ubiquitinated, talk
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