{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='Scientists Use Gene Therapy to Fight HIV' data-url='/boclips/videos/5c54d728d8eafeecae2097da' data-video-url='/boclips/videos/5c54d728d8eafeecae2097da' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nScientists Use Gene Therapy to Fight HIV\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eEVEN THE STRONGEST AIDS DRUGS COULDN'T FULLY CONTROL 52 YEAR OLD MATT CHAPPELL'S HIV INFECTION.               NOW HIS BODY CAN DO THAT ON ITS OWN.               SOUNDBITE (English) Matthew Chappell/Patient              \"I don't have to...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eEVEN THE STRONGEST AIDS DRUGS COULDN'T FULLY CONTROL 52 YEAR OLD MATT CHAPPELL'S HIV INFECTION. \u003cbr/\u003e              NOW HIS BODY CAN DO THAT ON ITS OWN. \u003cbr/\u003e              SOUNDBITE (English) Matthew Chappell/Patient\u003cbr/\u003e              \"I don't have to really deal with side effects from some of the medications that are out there.\"\u003cbr/\u003e              CHAPPELL WAS IN A STUDY IN 2014 THAT EDITED A GENE TO MAKE SOME OF HIS BLOOD CELLS RESISTANT TO HIV. \u003cbr/\u003e              CHAPPELL'S DOCTOR SAYS IT'S TECHNICALLY NOT A CURE BECAUSE THE VIRUS REMAINS.    \u003cbr/\u003e              BUT THIS COULD BE THE NEXT BEST THING.\u003cbr/\u003e              SOUNDBITE (English) Dr. Christopher Schiessl/One Medical Group\u003cbr/\u003e              \"Matt's gene therapy is not, it's not fully controlling his HIV but it is doing a fairly good job of suppressing the virus in his blood. \"\u003cbr/\u003e              CHAPPELL IS ONE OF THE LUCKY ONES.   \u003cbr/\u003e              ONLY A FEW OF THE 100 OTHERS IN THOSE EXPERIMENTS WERE ABLE TO STAY OFF HIV DRUGS FOR A COUPLE YEARS.  \u003cbr/\u003e              THE REST STILL NEED MEDICINES TO KEEP HIV SUPPRESSED.\u003cbr/\u003e              BUT SOME SEE IT AS A GOOD BEGINNING.  \u003cbr/\u003e              SOUNDBITE (English) Dr. Christopher Schiessl/One Medical Group\u003cbr/\u003e              \"I think all this gene editing technology is really going to play out in a good way for diseases like HIV.\u003cbr/\u003e              SANGAMO THERAPEUTICS CREATED THE GENE EDITING TOOL CALLED ZINC FINGERS NUCLEASES. \u003cbr/\u003e              THEY ARE USED TO EDIT T-CELLS, PART OF THE IMMUNE SYSTEM THAT HIV INFECTS.  \u003cbr/\u003e              SOUNDBITE (English) Sandy Macrae/Sangamo Therapeutics\u003cbr/\u003e              \" If we take the immune cell from the patient, then we edit with zinc fingers/But we do it outside the body.  Then we give the patients back the edited T-cells.\"\u003cbr/\u003e              SCIENTISTS REMOVED SOME OF CHAPPELL'S BLOOD THROUGH AN IV.\u003cbr/\u003e              DNA INSTRUCTIONS TO MAKE THE GENE EDITING TOOL ARE SENT INTO THE CELLS.\u003cbr/\u003e              THE EDITING TOOL SNIPS OUT PART OF A GENE THAT HELPS HIV ENTER.\u003cbr/\u003e              THE MODIFIED CELLS THAT NOW CAN RESIST INFECTION ARE NOW RETURNED TO HIM\u003cbr/\u003e              MANY SCIENTISTS ARE TRYING DIFFERENT WAYS TO IMPROVE THE THERAPY -- WITH FUNDING FROM THE NATIONAL INSTITUTES OF HEALTH. \u003cbr/\u003e              SOUNDBITE (English) Dr. Anthony Fauci/National Institutes of Health \u003cbr/\u003e              \" Very bold, innovative techniques mostly to try and cure people who are HIV infected.\"\u003cbr/\u003e              ONE STUDY IS DOING A TWO - STEP APPROACH.     \u003cbr/\u003e              AT THE UNIVERSITY OF PENNSYLVANIA, SCIENTIST JAMES RILEY IS TRYING TO DO THE SAME EDITING CHAPPELL HAD -- PLUS ADDING A GENE TO HELP CELLS RECOGNIZE AND KILL HIV. \u003cbr/\u003e              SOUNDBITE (English) James Riley/Perelman School of Medicine, University of Pennsylvania\u003cbr/\u003e              \"We're trying to see if we can get a long- term remission.  To get people off their current therapy and see if the cells can replace that, and ultimately see if we can rid them of HIV. \"\u003cbr/\u003e              CHAPPELL BELIEVES THE THERAPY HAS GIVEN HIM THE GIFT OF TIME.  \u003cbr/\u003e              SOUNDBITE (English) Matthew Chappell\u003cbr/\u003e              \"If you were to ask me in the early nineties if I'd be sitting here right now. no way. \"\u003cbr/\u003e              GIVING HIM HOPE THAT HE AND OTHERS MAY NOT NEED HIV TREATMENT IN THE FUTURE. \u003cbr/\u003e              KATHY YOUNG, ASSOCIATED PRESS.\u003cbr/\u003e            \u003cbr/\u003e\u003cbr/\u003e              San Francisco - January 26, 2018\u003cbr/\u003e              1. Various shots of patient Matt Chappell getting a checkup with his doctor Christopher Schiessl\u003cbr/\u003e              2. SOUNDBITE (English) Matt Chappell, Patient (transcript below)\u003cbr/\u003e              3. Various shots of Matt Chappell continuing his checkup\u003cbr/\u003e              4. SOUNDBITE (English) Dr. Christopher Schiessl, One Medical Group (transcript below)\u003cbr/\u003e              5. Medium shot of Chappell speaking with his doctor\u003cbr/\u003e              \u003cbr/\u003e              Washington DC - July 26, 2012\u003cbr/\u003e              10. Close up of HIV medications\u003cbr/\u003e              11. Wide of pill organizer and medicine bottles\u003cbr/\u003e              12. Medium of pill organizer\u003cbr/\u003e              13. Tight shot of HIV pill bottles\u003cbr/\u003e              \u003cbr/\u003e              San Francisco - January 26, 2018\u003cbr/\u003e              14. Wide of Dr. Christopher Schiessl typing\u003cbr/\u003e              15. SOUNDBITE (English) Dr. Christopher Schiessl, One Medical Group (transcript below)\u003cbr/\u003e              \u003cbr/\u003e              Richmond, California -  November 2, 2017\u003cbr/\u003e              ++FILE++\u003cbr/\u003e              16. Wide of machine used to make Zinc Fingers Nucleases\u003cbr/\u003e              17. Medium shot of plastic tubes being dispersed \u003cbr/\u003e              18. Medium shot of researcher inspecting the machine\u003cbr/\u003e              19. Close up of Laboratory Automation Workstation\u003cbr/\u003e              20 SOUNDBITE (English) Sandy Macrae, President, Sangamo Therapeutics ++partially covered++\u003cbr/\u003e              (transcript below)\u003cbr/\u003e              \u003cbr/\u003e              ++ANIMATION++ ++MUTED++\u003cbr/\u003e              21. Animation of the gene therapy used on Matt Chappell\u003cbr/\u003e              \u003cbr/\u003e              Richmond, California -  November 2, 2017\u003cbr/\u003e              ++FILE++\u003cbr/\u003e              22. Wide shot of researcher \u003cbr/\u003e              23. Close up of researcher's face\u003cbr/\u003e              24. Wide of researcher\u003cbr/\u003e              \u003cbr/\u003e              Washington DC - January 18, 2018\u003cbr/\u003e              ++AUDIO AS INCOMING++\u003cbr/\u003e              25. SOUNDBITE (English) Dr. Anthony Fauci, National Institutes of Health (transcript below)\u003cbr/\u003e              \u003cbr/\u003e              Philadephia - January 22, 2018\u003cbr/\u003e              26. Medium of scientist James Riley at computer\u003cbr/\u003e              27. Close up of scientist James Riley typing\u003cbr/\u003e              28. Close up of scientist James Riley's face\u003cbr/\u003e              \u003cbr/\u003e              Richmond, California -  November 2, 2017\u003cbr/\u003e              ++FILE++\u003cbr/\u003e              29.  Medium shot of Assembly Primer machine\u003cbr/\u003e              30. Close up of machine\u003cbr/\u003e              \u003cbr/\u003e              Philadephia - January 22, 2018\u003cbr/\u003e              31. SOUNDBITE: (English) James Riley, University of Pennsylvania (transcript below)\u003cbr/\u003e              \u003cbr/\u003e              San Francisco - January 26, 2018\u003cbr/\u003e              32. Chappell walking on street\u003cbr/\u003e              33. SOUNDBITE (English) Matt Chappell, Patient (transcript below)\u003cbr/\u003e              34. Medium shot of Chappell walking\u003cbr/\u003e              35. 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