{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='Study Backs Cell Transplants for Severe Diabetes' data-url='/boclips/videos/5c54caf8d8eafeecae1a03fe' data-video-url='/boclips/videos/5c54caf8d8eafeecae1a03fe' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nStudy Backs Cell Transplants for Severe Diabetes\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eTransplants of insulin-producing pancreas cells are a long hoped-for treatment for diabetes — and a new study shows they can protect the most seriously ill patients from a life-threatening complication of the disease, an important...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eTransplants of insulin-producing pancreas cells are a long hoped-for treatment for diabetes — and a new study shows they can protect the most seriously ill patients from a life-threatening complication of the disease, an important step toward U.S. approval.These transplants are used in some countries but in the U.S. they're available only through research studies. Armed with Monday's findings, researchers hope to license them for use in a small number of people with Type 1 diabetes who are most at risk for drops in blood sugar so severe they can lead to seizures, even death.In Type 1 diabetes, the immune system destroys the pancreatic cells responsible for making insulin, a hormone crucial to converting blood sugar into energy. When glucose levels drop too low, most people with Type 1 diabetes experience early warning signs — slurred speech, tremors, sweating, heart palpitations — so they know to eat or drink something for a quick sugar boost. But even with optimal care, about 30 percent eventually quit experiencing those symptoms, a condition called hypoglycemia unawareness. They can be in grave danger if their blood sugar plummets when no one else is around to help. Continuous glucose monitors can counteract that problem, but even those don't help everyone.The National Institutes of Health targeted that fraction of highest-risk patients, funding a study that gave 48 people at eight medical centers at least one islet cell transplant.A year later, 88 percent were free of severe hypoglycemia events, had their awareness of blood sugar dips restored, and harbored glucose levels in near-normal ranges. Two years later, 71 percent of participants still were faring that well, concluded the study published by the journal Diabetes Care.Transplants of insulin-producing pancreas cells are a long hoped-for treatment for diabetes — and a new study shows they can protect the most seriously ill patients from a life-threatening complication of the disease, an important step toward U.S. approval.These transplants are used in some countries but in the U.S. they're available only through research studies. Armed with Monday's findings, researchers hope to license them for use in a small number of people with Type 1 diabetes who are most at risk for drops in blood sugar so severe they can lead to seizures, even death.In Type 1 diabetes, the immune system destroys the pancreatic cells responsible for making insulin, a hormone crucial to converting blood sugar into energy. When glucose levels drop too low, most people with Type 1 diabetes experience early warning signs — slurred speech, tremors, sweating, heart palpitations — so they know to eat or drink something for a quick sugar boost. But even with optimal care, about 30 percent eventually quit experiencing those symptoms, a condition called hypoglycemia unawareness. They can be in grave danger if their blood sugar plummets when no one else is around to help. Continuous glucose monitors can counteract that problem, but even those don't help everyone.The National Institutes of Health targeted that fraction of highest-risk patients, funding a study that gave 48 people at eight medical centers at least one islet cell transplant.A year later, 88 percent were free of severe hypoglycemia events, had their awareness of blood sugar dips restored, and harbored glucose levels in near-normal ranges. Two years later, 71 percent of participants still were faring that well, concluded the study published by the journal Diabetes Care.AP TELEVISIONRockville, Maryland - 18 April 20161. Wide of Dr. Nancy Bridges2. SOUNDBITE (English) Dr. Nancy Bridges, chief of the transplant branch at NIH's National Institute for Allergy and Infectious Diseases:\"Islets are clusters of cells that reside in the Pancreas and their function is to secrete hormones that control blood sugar so essentially a person with a normally functioning pancreas maintains their blood sugar within a very narrow range no matter what you eat.\"AP PHOTOS - NO ACCESS CANADA/BROADCAST USE ONLY/STRICTLY NO ACCESS ONLINE OR MOBILELos Angeles - 22 August 20083. STILL of fresh produceAP TELEVISIONRockville, Maryland - 18 April 20164. SOUNDBITE (English) Dr. Nancy Bridges, chief of the transplant branch at NIH's National Institute for Allergy and Infectious Diseases:\"What we're dealing with in this study is people who have Type 1 diabetes. In Type 1 diabetes the patient has an auto-immune disorder in which their own immune system destroys the islet cells in the Pancreas so that they no longer make any insulin.\"AP PHOTOS - NO ACCESS CANADA/BROADCAST USE ONLY/STRICTLY NO ACCESS ONLINE OR MOBILECommerce, California - 29 April 20125. STILL of woman injecting insulinAP TELEVISIONRockville, Maryland - 18 April 20166. SOUNDBITE (English) Dr. Nancy Bridges, chief of the transplant branch at NIH's National Institute for Allergy and Infectious Diseases:\"Normally, a person with diabetes or a person who doesn't have diabetes gets symptoms when their blood sugar is low. So you may get tremulous, start to shake or you start to sweat, or you get very irritable and you know you have to eat something. But for a subset of people with Type I diabetes, they lose that awareness so they have what's called hypoglycemia unawareness, or impaired awareness of hypoglycemia. Those people can get into serious trouble because their blood sugar will continue to drop until it's so low that they're incapacitated and they can no longer help themselves. They can't walk to the refrigerator and get some orange juice or do something else to help themselves. They may have seizures, the may just become unconscious and people can die from this.\"AP PHOTOS - NO ACCESS CANADA/BROADCAST USE ONLY/STRICTLY NO ACCESS ONLINE OR MOBILECommerce, California - 29 April 20127. STILL of a closeup of someone giving an insulin injectionAP TELEVISIONRockville, Maryland - 29 April 20168. SOUNDBITE (English) Dr. Nancy Bridges, chief of the transplant branch at NIH's National Institute for Allergy and Infectious Diseases:\"So I think what we've demonstrated with this study is number one, islet transplantation can eradicate severe hypoglycemic events while providing better control of blood sugar than any other therapy that's been tried in this particular population of patients and that multiple sites can follow the same procedures, very complicated manufacturing procedure, to produce comparable islets which can be characterized completely enough that they should meet the bar for approval by a regulatory agency, that is by the FDA.\"   9. 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