{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='New scanning technique to improve  bone marrow cancer treatment ++EMBARGOED++' data-url='/boclips/videos/5c54c4c1d8eafeecae16b072' data-video-url='/boclips/videos/5c54c4c1d8eafeecae16b072' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nNew scanning technique to improve  bone marrow cancer treatment ++EMBARGOED++\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eRodney Benjamin thanks medical science for the fact that he's still alive.Benjamin lives on Guernsey, one of the Channel Islands off Britain's southern coast, and he flew himself in for today's special scan at the Royal Marsden...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eRodney Benjamin thanks medical science for the fact that he's still alive.\u003cbr/\u003eBenjamin lives on Guernsey, one of the Channel Islands off Britain's southern coast, and he flew himself in for today's special scan at the Royal Marsden Hospital.\u003cbr/\u003eFlying is a pleasurable pass time, one he hope to continue long into the future despite the disease which he has fought for nearly ten years. \u003cbr/\u003eBenjamin is now 69 years old, but in March 2004 he discovered he had myeloma.\u003cbr/\u003eIt's a bone marrow cancer which affects the plasma cells which are important to the immune system.\u003cbr/\u003eAccording to the Institute of Cancer Research these cells grow uncontrollably in bone marrow and become stuck there.\u003cbr/\u003eThis disrupts the production of normal blood cells and it can spread in bones throughout the body including the skull, ribs, the spine and in the arms and legs. \u003cbr/\u003eFor a long time Benjamin suffered back pain without seeking help.\u003cbr/\u003eEventually his GP sent him to hospital where doctors were alarmed enough to put him in an air ambulance bound for a larger hospital on the UK mainland.\u003cbr/\u003eIt was the last time Benjamin took his health for granted.\u003cbr/\u003eHe has had an array of radiation therapies, an autologous stem cell transplantation and chemotherapy drugs, along with numerous drugs to manage their side effects including peripheral neuropathy where the long nerves in feet and hands become numb.\u003cbr/\u003eBenjamin is one of the 26 myeloma patients who took part in the Royal Marsden's small pilot study funded by Britain's Institute of Cancer Research.\u003cbr/\u003eDescribing how he copes with his disease he says: \"It's a bit like being chased by an animal all the time, a dangerous animal. If you stop and look round and it catches up with you, you're done for. I've known many patients who didn't manage to keep ahead.\"\u003cbr/\u003eThis scanning technique is called whole-body, diffusion-weighted MRI because it uses a measurement called the Apparent Diffusion Coefficient (ADC), which records how restricted water movement is within tissues. \u003cbr/\u003eWater movement is more restricted in tumours because their high cell density restricts the movement of extracellular water.\u003cbr/\u003eFor Benjamin it's another vital tool with which to fight his cancer.\u003cbr/\u003eHe says: \"Having regular imaging such as the MRI, having regular blood tests, keeping ahead, keeping in touch with all the medication that you need is absolutely crucial.\"\u003cbr/\u003eThe lead researcher on the study was the Institute of Cancer Research's Professor of Translational Imaging Nandita deSouza.\u003cbr/\u003eProfessor deSouza believes this form of imaging has the potential for increasing for not only pinpointing all of the cancer within a patient's body, but enabling doctors to treat the cancer more effectively by being able to accurately measure the amount of drugs or radiotherapy needed.\u003cbr/\u003eShe says: \"The extent of disease is imaged using standard X-rays. This means taking individual X-rays of every bone in the body. That's quite intensive in terms of X-Radiation to a patient, but also it doesn't actually pick up disease until there's significant bone destruction, so there's not an early method of picking up the disease in the marrow in myeloma.\"\u003cbr/\u003eLooking at this screen you can see the cancer within the bone marrow, it's the dark patches around the spine in the shoulders and the pelvis.\u003cbr/\u003eThe next skeleton shows the same patient after treatment, the black patches are drastically reduced.\u003cbr/\u003eMost cancers are detected, or confirmed through biopsies, but when it comes to bone marrow patients doctors are anxious.\u003cbr/\u003eAccording to deSouza: \"Doing a bone biopsy is a very painful thing for a patient.  Multiple bone biopsies are not something a patient would want to undergo. Also bone biopsies are limited in that you take a biopsy from a particular area of the bone and you cannot biopsy the whole skeleton. So having a scanning technique that's sensitive, images diseases within the marrow and looks at the whole skeleton at the same time is something that's very desirable.\"\u003cbr/\u003eProfessor deSouza's research is published today (January 28, 2014 18.00 GMT) in the journal Radiology.\u003cbr/\u003eScans like these can accurately monitor how myeloma patients are responding to treatment.\u003cbr/\u003eIt allows doctors to make better informed decisions, enabling them to respond quickly and change drugs therapies that aren't working. \u003cbr/\u003eAccording to the study the patients had whole-body, diffusion-weighted MRI scans before and after treatment. \u003cbr/\u003eIn 86% of cases, experienced doctors trained in imaging were able to correctly identify whether patients responded to treatment. \u003cbr/\u003eThe doctors also correctly identified those patients who weren't responding to treatment 80% of the time. \u003cbr/\u003eNearly 4,700 people are diagnosed with myeloma every year in the UK according to the ICR and it's the most common form of blood cancer. \u003cbr/\u003eThe UK's National Health Service (NHS) says for: \"most people with multiple myeloma there is no cure, but treatment can control the progression of the cancer for several years or, in some cases, many years\".\u003cbr/\u003eIt says: \"Age and fitness are also important factors, as well as the type of treatment you have. There are some very intensive treatments for myeloma, but to have them you often need to be otherwise fit and healthy.\"\u003cbr/\u003eBenjamin believes he owes his survival to the development of drugs used for myeloma patients.\u003cbr/\u003eBut he also admits: \"Unfortunately these things (drugs) don't work forever and since then (diagnosis in 2004) I've been on a variety, a bit of a rollercoaster, various relapses and back again in action.\"\u003cbr/\u003eResearchers at the Royal Marsden stress that the study is small and more studies are needed to refine the technology.\u003cbr/\u003eThey hope that in the future it will become a tool helping doctors to extend the life of more myeloma patients. \u003cbr/\u003eProfessor deSouza is hopeful they are moving in the right direction.\u003cbr/\u003eShe says \"Myeloma is a disease of bone marrow that affects the whole skeleton and so you need to assess it by looking at all the bones in the body.\"\u003cbr/\u003eRodney Benjamin is holding on for the next development in the treatment of myeloma.\u003cbr/\u003eHe says: \"The battle is quite simple. You become more and more resistant to the drugs, the specific drugs and you've always got to be ready to move on, but there are at least two new generations of exciting new developments coming on stream over the next year or two, so if I can last out that long and I can get onto these new drugs, then hope carries through so (the) development is very favourable, the prognosis isn't so good as it stands (now), but I remain optimistic.\"\u003cbr/\u003eBefore he retired Rodney Benjamin was an actuary,  and regularly calculated mortality tables,  so it's with black amusement that he considers his own survival.\u003cbr/\u003eHe says his primary objective in life is to die from something other than myeloma.\u003cbr/\u003eSurrey, UK, January 27, 2014\u003cbr/\u003e1. Mid of nurses getting cancer patient Rodney Benjamin into position for whole body diffusion MRI scan\u003cbr/\u003e2. Close zoom out of Benjamin lying down and being raised to the entrance of the scan \u003cbr/\u003e3. Close of nurse \u003cbr/\u003e4. Various of nurses preparing Benjamin for scan  \u003cbr/\u003e5. Mid of Benjamin entering scan watched by radiographer and nurse \u003cbr/\u003e6. Mid of radiographer closing door to scanning area and zoom into seal on door \u003cbr/\u003e7. SOUNDBITE: (English), Rodney Benjamin, myeloma patient   \u003cbr/\u003e\"It's a bit like being chased by an animal all the time, a dangerous animal. If you stop and look round and it catches up with you, you're done for. I've known many patients who didn't manage to keep ahead.\"\u003cbr/\u003e8. Close of Benjamin in MRI scanner shot through copper glass window\u003cbr/\u003e9. Close of radiographer's monitors showing patient in scanner (left) and spine being scanned (right)\u003cbr/\u003e10. SOUNDBITE: (English), Rodney Benjamin, myeloma patient   \u003cbr/\u003e\"Having regular imaging such as the MRI, having regular blood tests, keeping ahead, keeping in touch with all the medication that you need is absolutely crucial.\"\u003cbr/\u003e11. Mid pan from bookshelves to Professor of Translational Imaging Nandita deSouza looking at scans in her office \u003cbr/\u003e12. Close of deSouza looking at scans on computer screen \u003cbr/\u003e13. Close of screen showing pre and post treatment shots of myeloma patients \u003cbr/\u003e14. Close of deSouza \u003cbr/\u003e15. Close of screen\u003cbr/\u003e16. SOUNDBITE: (English), Professor Nandita deSouza, The Institute of Cancer Research, Honorary Consultant, The Royal Marsden Hospital, \u003cbr/\u003e\"The extent of disease is imaged using standard X-rays. This means taking individual X-rays of every bone in the body. That's quite intensive in terms of X-Radiation to a patient, but also it doesn't actually pick up disease until there's significant bone destruction, so there's not an early method of picking up the disease in the marrow in myeloma.\"\u003cbr/\u003e17. Close tilt up of scan showing body of patient before treatment (black areas particularly around spine between shoulders and pelvis show bone marrow cancer)\u003cbr/\u003e18. Close pan from scan showing patient's pelvis before treatment to scan after treatment \u003cbr/\u003e19. SOUNDBITE: (English), Professor Nandita deSouza, The Institute of Cancer Research, Honorary Consultant, The Royal Marsden Hospital, \u003cbr/\u003e\"Doing a bone biopsy is a very painful thing for a patient.  Multiple bone biopsies are not something a patient would want to undergo. Also bone biopsies are limited in that you take a biopsy from a particular area of the bone and you cannot biopsy the whole skeleton. So having a scanning technique that's sensitive, images disease within the marrow and looks at the whole skeleton at the same time is something that's very desirable.\"\u003cbr/\u003e20. Mid profile of radiographer speaking to Benjamin through intercom\u003cbr/\u003e21. Pull to focus on close of scan \u003cbr/\u003e22. Mid of nurse communicating with Benjamin on intercom \u003cbr/\u003e23. Close pan of MRI scans being collected on monitor\u003cbr/\u003e24. SOUNDBITE: (English), Rodney Benjamin, myeloma patient  \u003cbr/\u003e\"Unfortunately these things (drugs) don't work forever and since then (diagnosis in 2004) I've been on a variety, a bit of a rollercoaster, various relapses and back again in action.\"\u003cbr/\u003e25. Various close of Benjamin's scans on radiographer's screen \u003cbr/\u003e26. SOUNDBITE: (English), Professor Nandita deSouza, The Institute of Cancer Research, Honorary Consultant, The Royal Marsden Hospital, \u003cbr/\u003e\"Myeloma is a disease of bone marrow that affects the whole skeleton and so you need to assess it by looking at all the bones in the body.\"\u003cbr/\u003e27. SOUNDBITE: (English), showing mid rear view of radiographer talking to Benjamin over the intercom \u003cbr/\u003e\"Breathe in, breathe out, now breathe in and hold your breath in.\" \u003cbr/\u003e28. Zoom out from close of monitor showing scanner holding Benjamin in next room with intercom open with noise of scanner \u003cbr/\u003e29. Close of MRI scanner shot through window onto scanning room \u003cbr/\u003e30. SOUNDBITE: (English), Rodney Benjamin, myeloma patient   \u003cbr/\u003eThe battle is quite simple. You become more and more resistant to the drugs, the specific drugs and you've always got to be ready to move on, but there are at least two new generations of exciting new developments coming on stream over the next year or two, so if I can last out that long and I can get onto these new drugs, then hope carries through so (the) development is very favourable, the prognosis isn't so good as it stands (now), but I remain optimistic.\"\u003cbr/\u003e31. Various of radiographer and nurse unstrapping equipment holding Benjamin in place on scanner \u003cbr/\u003e32. Close of Benjamin \u003cbr/\u003e33. Mid of Benjamin's feet\u003cbr/\u003e34. Wide of Benjamin being lowered by nurse \u003cbr/\u003e35. Close of nurse \u003cbr/\u003e36. 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