{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='BEATING HEART CELLS MADE FROM PATIENT\u0026#39;S SKIN' data-url='/boclips/videos/5c54c3d6d8eafeecae16447a' data-video-url='/boclips/videos/5c54c3d6d8eafeecae16447a' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nBEATING HEART CELLS MADE FROM PATIENT\u0026#39;S SKIN\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eHaifa, May 23, 20121. Close of monitor showing microscope view of beating cells in the Rambam Medical Centre laboratory  2. Mid of researcher at the microscope zoom out and pan to monitor3. Close zoom in of beating cells on monitor 4....\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eHaifa, May 23, 2012\u003cbr/\u003e1. Close of monitor showing microscope view of beating cells in the Rambam Medical Centre laboratory  \u003cbr/\u003e2. Mid of researcher at the microscope zoom out and pan to monitor\u003cbr/\u003e3. Close zoom in of beating cells on monitor \u003cbr/\u003e4. Mid of researcher at microscope \u003cbr/\u003e5. Various close of beating cells \u003cbr/\u003e6. SOUNDBITE: (English), Professor Lior Gepstein, Rambam Medical Centre, electrophysiology research laboratory\u003cbr/\u003e\"The heart cells that were generated were young and healthy and resembled the heart cells of that specific patient at the day that he was born, in contrast to the heart of the heart failure patient which was extremely dysfunctional and all the cells were very, very dysfunctional.\"\u003cbr/\u003e7. Mid of researchers putting dish with cells onto electrical charge  \u003cbr/\u003e8. Close of dish being locked into unit \u003cbr/\u003e9. Various close of computer screen showing activity in reprogrammed heart cells \u003cbr/\u003e10. Mid of researchers reading screen \u003cbr/\u003e11. Close of screen \u003cbr/\u003e12. Wide of researchers \u003cbr/\u003e13. SOUNDBITE: (English), Professor Lior Gepstein, Rambam Medical Centre, electrophysiology research laboratory\u003cbr/\u003e\"We also demonstrated that the cells could be engrafted into the in vivo heart in an animal model and that the transplanted heart cells could integrate with the existing tissue and beat in synchrony with existing tissue.\"\u003cbr/\u003e14. Mid of researcher walking to open incubator and remove a box of growing stem cells \u003cbr/\u003e15. Close of dishes in box\u003cbr/\u003e16. Various of researcher feeding cells in dishes \u003cbr/\u003e17. SOUNDBITE: (English), Professor Lior Gepstein, Rambam Medical Centre, electrophysiology research laboratory\u003cbr/\u003e\"Despite the significant improvements that were done in the last decade, or two decades in cardiology that involves medical treatment, surgery, coronary interventions, still the number of patients that have heart failure is continuing to grow, more patients survive heart attacks, more patients live to an older age and the number of patients suffering from heart failure is continuing to grow.\" \u003cbr/\u003e18. Mid of researcher looking at microscope monitor \u003cbr/\u003e19. Close of beating cells on monitor \u003cbr/\u003e20. Mid rear view of researcher\u003cbr/\u003e21. Close of dishes being moved under microscope \u003cbr/\u003e22. Various of researcher \u003cbr/\u003e23. SOUNDBITE: (English), Professor Lior Gepstein, Rambam Medical Centre, electrophysiology research laboratory\u003cbr/\u003e\"Bypass surgery does not regenerate a dead area in the heart. It can improve the vascularisation, improve the functions of suffering cells, but it cannot replace cells that died that were replaced by a scar.\"\u003cbr/\u003e24. Close of monitor showing microscope image of skin cells \u003cbr/\u003e25. Close of monitor showing microscope image of stem cells being grown\u003cbr/\u003e26. Close of monitor showing microscope image of beating cells \u003cbr/\u003e27. SOUNDBITE: (English), Professor Lior Gepstein, Rambam Medical Centre, electrophysiology research laboratory\u003cbr/\u003e\"We know that there are certain cues that guide the different creation of early cells to become heart cells to not become liver cells and so on, for example we know that the area that will become the stomach in the developing embryo secretes certain that affect neighbouring cells to become the heart. That's why people say the ways to a man's heart is through his stomach.\"\u003cbr/\u003e28. Wide of laboratory \u003cbr/\u003e29. Mid of researcher in laboratory \u003cbr/\u003e30. SOUNDBITE: (English), Professor Lior Gepstein, Rambam Medical Centre, electrophysiology research laboratory\u003cbr/\u003e\"We are only making cardiac cells and tissue and we find it extremely difficult. Imagine making an entire organ from different cells, already in the right place so it lets you appreciate the biological system and process that are involved in development that have been perfected during evolution and it's so hard to imitate in the dish.\"\u003cbr/\u003e31. Wide of researchers in laboratory\u003cbr/\u003eScientists claim they've transformed skin cells from two elderly men suffering heart disease into healthy heart cells in a laboratory.\u003cbr/\u003eThe graft using an animal model is another step to perfecting stem cell technology which could one day help to tackle a disease which is on the increase in almost every region of the world.\u003cbr/\u003eIt's a highly magnified spot under the microscope.\u003cbr/\u003eThe bit that's moving is a cluster of heart cells and they're seen to be beating like a heart. \u003cbr/\u003eResearchers in this team took skin cells from a very sick patient with diseased and dysfunctional heart cells.\u003cbr/\u003eThese were then reprogrammed to become induced pluripotent stem cells, which given the right cues and growth media can make cells for a number of organs.\u003cbr/\u003eIn this laboratory they're creating heart cells, and more significantly they're healthy heart cells despite coming from a sick patient.\u003cbr/\u003eThe most obvious benefit of this form of therapy is that there would be none of the tissue rejection normally associated with transplants.\u003cbr/\u003eLead researcher Professor Lior Gepstein is a cardiologist as well as being an electro-physiologist. \u003cbr/\u003eHe splits his time between Haifa's Rambam Medical Centre and the the Technion-Israel Institute of Technology.\u003cbr/\u003eGepstein says: \"The heart cells that were generated were young and healthy and resembled the heart cells of that specific patient at the day that he was born in contrast to the heart of the heart failure patient which was extremely dysfunctional and all the cells were very, very dysfunctional.\"\u003cbr/\u003eHe's particularly encouraged by the fact that: \"We also demonstrated that the cells could be engrafted into the in vivo heart in an animal model and that the transplanted heart cells could integrate with the existing tissue and beat in synchrony with existing tissue.\"\u003cbr/\u003eBut just because the muscle beats like a heart doesn't mean that Gepstein and his team don't still face enormous obstacles.\u003cbr/\u003eProducing this small amount of muscle in a petri dish requires the production of a million, or so cells.\u003cbr/\u003eTo even begin thinking of regenerative muscle for a human heart would require many billions. \u003cbr/\u003eIt's also important for the team to ensure any tissue they produce is not predisposed to the growth of cancer tumours.\u003cbr/\u003eA major drawback for these researchers at the moment is that the heart cells they produce don't have a long shelf life. \u003cbr/\u003eThere have been remarkable advances in heart surgery over the past two decades, but Gepstein is still convinced that ultimately doctors will need to turn to stem cell therapy.  \u003cbr/\u003eHe argues: \u003cbr/\u003e\"Despite the significant improvements that were done in the last decade, or two decades in cardiology that involves medical treatment, surgery, coronary interventions, still the number of patients that have heart failure is continuing to grow, more patients survive heart attacks, more patients live to an older age and the number of patients suffering from heart failure is continuing to grow.\" \u003cbr/\u003eGepstein says: \"Bypass surgery does not regenerate a dead area in the heart. It can improve the vascularisation, improve the functions of suffering cells, but it cannot replace cells that died that were replaced by a scar.\"\u003cbr/\u003eHeart disease is the fourth biggest killer in the world according to World Health Organisation figures. \u003cbr/\u003eIt caused 57 million deaths last year.\u003cbr/\u003eBut research into stem cell therapy is not a quick, cheap option.\u003cbr/\u003eGetting these skin cells to become these stem cells and ultimately this muscle, has relied on decades of accumulated knowledge from research in laboratories like this around the world.\u003cbr/\u003eGepstein says:\u003cbr/\u003e\"We know that there are certain cues that guide the different creation of early cells to become heart cells to not become liver cells and so on, for example we know that the area that will become the stomach in the developing embryo secretes certain that affect neighbouring cells to become the heart. That's why people say the ways to a man's heart is through his stomach.\"\u003cbr/\u003eThat may be a joke with more than a pinch of truth about it.\u003cbr/\u003eGepstein is aware that turning what's happening here into regenerative medicine in a hospital will be a very long haul and he doesn't underestimate the difficulties.\u003cbr/\u003eHe says: \"We are only making cardiac cells and tissue and we find it extremely difficult. Imagine making an entire organ from different cells, already in the right place so it lets you appreciate the biological system and process that are involved in development that have been perfected during evolution and it's so hard to imitate in the dish.\"\u003cbr/\u003eThe study published in the European Heart Journal says clinical trials of the technique are at least a decade away.\u003cbr/\u003eClients are reminded: \u003cbr/\u003e(i) to check the terms of their licence agreements for use of content outside news programming and that further advice and assistance can be obtained from the AP Archive on: Tel +44 (0) 20 7482 7482 Email: info@aparchive.com. \u003cbr/\u003e(ii) they should check with the applicable collecting society in their Territory regarding the clearance of any sound recording or performance included within the AP Television News service \u003cbr/\u003e(iii) they have editorial responsibility for the use of all and any content included within the AP Television News 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