{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='WRAP Trial finds AIDS vaccine cuts risk of HIV infection, reax' data-url='/boclips/videos/5c54c311d8eafeecae15e7bf' data-video-url='/boclips/videos/5c54c311d8eafeecae15e7bf' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nWRAP Trial finds AIDS vaccine cuts risk of HIV infection, reax\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eBangkok - Recent 1. Zoom in to laboratory staff member working in the laboratory 2. Close of samples 3. Various of laboratory staff working4. Close of samples 5. Sample being scanned into databaseBangkok - 24 September 20096. SOUNDBITE...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eBangkok - Recent \u003cbr/\u003e1. Zoom in to laboratory staff member working in the laboratory \u003cbr/\u003e2. Close of samples \u003cbr/\u003e3. Various of laboratory staff working\u003cbr/\u003e4. Close of samples \u003cbr/\u003e5. Sample being scanned into database\u003cbr/\u003eBangkok - 24 September 2009\u003cbr/\u003e6. SOUNDBITE (English) Dr. Supachai Rerks-Ngarm, Director of the AIDS Vaccine Trial: \u003cbr/\u003e\"This is a scientific breakthrough. This is the first that we can prove that a vaccine can be developed to prevent infection among the vaccinees, which is the first stepping stone for further vaccine development.\" \u003cbr/\u003eBangkok - 24 September 2009\u003cbr/\u003e7. Wide of news conference\u003cbr/\u003e8. Reporter taking notes from vaccine report \u003cbr/\u003e9. Close of vaccine report \u003cbr/\u003e10. SOUNDBITE (Thai) Witthaya Kaewparadai, Thai minister of public health:\u003cbr/\u003e\"Now the trial has ended and the result is that the percentage of prevention is 31 percent. Although it hasn't reached what we hoped for, it's an important step.\"\u003cbr/\u003e11. Cutaway of audience\u003cbr/\u003e12. SOUNDBITE (English) Eric G. John, US ambassador to Thailand:\u003cbr/\u003e\"In the international scientific and medical communities around the globe, this trial will be recognised as a testament to Thailand's ability to successfully execute a complicated vaccine trial - the largest ever attempted - that ended with a credible conclusion and that brought us one step closer to an HIV vaccine.\"\u003cbr/\u003e13. Wide of news conference \u003cbr/\u003e14. Mid of Colonel Arthur E. Brown (right) and Colonel James Boles, commanders of Armed Forces Research Institute of Medical Sciences \u003cbr/\u003eBangkok - 24 September 2009\u003cbr/\u003e15. Thanad Yomha, volunteer on community advisory board for vaccine trial, at vaccine results news conference\u003cbr/\u003eBangkok - 24 September 2009\u003cbr/\u003e16. Wide Thanad taking questions from reporters \u003cbr/\u003e17. Various of Thanad answering questions regarding trial\u003cbr/\u003e18. SOUNDBITE (Thai) Thanad Yomha, Volunteer on community advisory board for vaccine trial:\u003cbr/\u003e\"I didn't expect anything. I did this for others and as for me, considering how old I am, what we all do now is for the next generation.\"\u003cbr/\u003e19. Wide of Maureen Birmingham, World Health Organisation representative in Bangkok, answering questions at vaccine results news conference 20. SOUNDBITE (English) Maureen Birmingham, World Health Organisation representative in Bangkok:\u003cbr/\u003e\"It is the largest trial ever conducted, successfully conducted trial with the highest ethical standards, and it has some, although albeit modest, results, some very encouraging results that can be used to guide further efforts in vaccine development, research and development for HIV. So it's of course very encouraging also to the global community, these kinds of results, it gives us hope for future vaccine development against our fight and against HIV.\"\u003cbr/\u003e21. Wide of Vimit Thienudom, director of non-profit AIDSAccess, talking to reporters\u003cbr/\u003e22. SOUNDBITE (Thai) Vimit Thienudom, Director of non-profit group AIDSAccess:\u003cbr/\u003e\"Although the result is lower than what we expected and the vaccine can't be used to prevent infection today, the trial process gave the Thai scientists and communities a learning experience which will be valuable for future studies.\"\u003cbr/\u003eVillage in Rayong province, south west of Bangkok - 24 September 2009\u003cbr/\u003e23. Thanad Yomha, volunteer on community advisory board for vaccine trial walking in one of the villages where trial was conducted\u003cbr/\u003e24. Thanad meeting other volunteers, handing out information on trial\u003cbr/\u003e25. Thanad talking to another volunteer\u003cbr/\u003e26. Close of information leaflet \u003cbr/\u003e27. Various of volunteers talking in one of the villages where trial was conducted\u003cbr/\u003eResearchers in Thailand on Thursday announced that for the first time, an experimental vaccine prevented infection with the AIDS virus - a surprising result and a watershed event in the battle against the deadly epidemic. \u003cbr/\u003eRecent failures had led many scientists to think such a vaccine might never be possible.\u003cbr/\u003eBut presenting the findings of the world's largest AIDS vaccine trial of more than 16-thousand volunteers in Thailand, researchers said that a combination of two previously unsuccessful vaccines cut the risk of becoming infected with HIV by more than 31 percent.\u003cbr/\u003eThe trial - conducted by Thailand's Ministry of Public Health and sponsored in part by the US army - tested a two-vaccine combo in a \"prime-boost\" approach, where the first one primes the immune system to attack HIV and the second one strengthens the response.\u003cbr/\u003eThe study used strains of HIV common in Thailand and whether such a vaccine would work against other strains in the US, Africa or elsewhere in the world remained unknown, the scientists stressed.\u003cbr/\u003eBut the Thai health minister told reporters on Thursday that the findings were \"an important step,\" and the US ambassador to Thailand said the development brought scientists \"one step closer to an HIV vaccine.\"\u003cbr/\u003eEven a marginally helpful vaccine could have a big impact. \u003cbr/\u003e\"This is the first that we can prove that a vaccine can be developed to prevent infection,\" said Dr. Supachai Rerks-Ngarm, the Thai Health Ministry\u003cbr/\u003eofficial who oversaw the trial. \u003cbr/\u003e\"This is a scientific breakthrough,\" he said.\u003cbr/\u003eEvery day, seven and a half thousand people worldwide are newly infected with HIV and two (m) million died of AIDS in 2007, the United Nations agency UNAIDS estimates.\u003cbr/\u003eThe vaccines used in the trial were ALVAC from Sanofi Pasteur, the vaccine division of French drugmaker Sanofi-Aventis, and AIDSVAX, originally developed by VaxGen and now held by Global Solutions for Infectious Diseases, a nonprofit group founded by some former VaxGen employees.\u003cbr/\u003eALVAC uses canarypox, a bird virus altered so it can't cause human disease, to ferry synthetic versions of three HIV genes into the body.\u003cbr/\u003eAIDSVAX contains a genetically engineered version of a protein on HIV's surface. \u003cbr/\u003eThe vaccines are not made from whole virus - dead or alive - and cannot cause HIV.\u003cbr/\u003eNeither vaccine in the study prevented HIV infection when tested individually in earlier trials and dozens of scientists had called the combination one futile when it began in 2003 - but the results proved the sceptics wrong.\u003cbr/\u003eThe study, which was also sponsored by the US National Institute of Allergy and Infectious Diseases, tested the combo in HIV-negative Thai men and women ages 18 to 30 at average risk of becoming infected. \u003cbr/\u003eHalf received four \"priming\" doses of ALVAC and two \"boost\" doses of AIDSVAX over six months. \u003cbr/\u003eThe others received dummy shots. No one knew who got what until the study ended.\u003cbr/\u003eThanad Yomha, a 33-year-old electrician from southeastern Thailand, said he didn't expect anything in return for volunteering for the project.\u003cbr/\u003e\"I did this for others,\" he said. \"It's for the next generation.\"\u003cbr/\u003eAll participants were given condoms, counselling and treatment for any sexually transmitted infections and were tested every six months for HIV. \u003cbr/\u003eAny who became infected were given free treatment with antiviral medicines.\u003cbr/\u003eParticipants were followed for three years after vaccination ended.\u003cbr/\u003eResults: New infections occurred in 51 of the eight thousand and 197 given vaccine and in 74 of the eight thousand and 198 who received dummy shots. \u003cbr/\u003eThat worked out to a 31 percent lower risk of infection for the vaccine group.\u003cbr/\u003eThe vaccine had no effect on levels of HIV in the blood of those who did become infected. \u003cbr/\u003eThat had been another goal of the study, seeing whether the vaccine could limit damage to the immune system and help keep infected people\u003cbr/\u003efrom developing full-blown AIDS.\u003cbr/\u003eThe study was done in Thailand because US army scientists did pivotal research in that country when the AIDS epidemic emerged there, isolating\u003cbr/\u003evirus strains and providing genetic information on them to vaccine makers.\u003cbr/\u003eThe Thai government also strongly supported the idea of doing the study.\u003cbr/\u003eEven though the benefit of the combo-vaccination announced on Thursday seems modest, the researchers said they were pleased by the outcome and the findings were welcomed by UN health officials and non-government organisations.\u003cbr/\u003eThe World Health Organisation's representative on Thursday said it gave \"hope for future vaccine development against our fight and against HIV.\"\u003cbr/\u003eAnd the director of AIDSAccess said that even though the vaccine could not be used to prevent infection at this moment in time, the trial gave scientists \"a learning experience which will be valuable for future studies.\"\u003cbr/\u003eIt is unclear whether vaccine makers will seek to license the two-vaccine combo in Thailand based on the findings announced on Thursday. \u003cbr/\u003eBefore the trial began, the US Food and Drug Administration said other studies would be needed before the vaccine could be considered for US licensing.\u003cbr/\u003eAlso unclear was whether the Thai volunteers who received dummy shots would now be offered the vaccine. \u003cbr/\u003eResearchers had said they would do so if the vaccine showed clear benefit, defined as reducing the risk of infection by at least 50 percent.\u003cbr/\u003eScientists still want to know how long protection will last, whether booster shots will be needed and whether the vaccine helps prevent infection in gay men and injection drug users, since it was tested mostly in heterosexuals in the Thai trial.\u003cbr/\u003eDetails of the 105 (m) million US dollars study will be given at a vaccine conference in Paris in October.\u003cbr/\u003eIt was the third big vaccine trial since 1983, when HIV was identified as the cause of AIDS. \u003cbr/\u003eIn 2007, Merck \u0026amp; Co. stopped a study of its experimental vaccine after seeing it did not prevent HIV infection. \u003cbr/\u003eLater analysis suggested the vaccine might even raise the risk of infection in certain men. \u003cbr/\u003eThe vaccine itself did not cause infection.\u003cbr/\u003eIn 2003, AIDSVAX flunked two large trials, the first late-stage tests of any AIDS vaccine at the time.\u003cbr/\u003e\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='action-container flex justify-between'\u003e\n\u003cbutton aria-expanded='false' aria-label='Read more description' class='rp-full-description' type='button'\u003e\n\u003ci class='fai fa-solid fa-align-left'\u003e\u003c/i\u003e\n\u003cspan 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