{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-572d6a42.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-f4d0de30.css\" media=\"all\" /\u003e\n\u003cdiv data-title='USA: NEW PILL UNVEILED IN AMERICA' data-url='/boclips/videos/5c54c2e7d8eafeecae15d352' data-video-url='/boclips/videos/5c54c2e7d8eafeecae15d352' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nUSA: NEW PILL UNVEILED IN AMERICA\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eEnglish/NatA new magic pill in medicine has been unveiled in New York City.This pill acts as a \"dimmer switch\" on the body's internal disease fighting system by adjusting the strength of the response to disease by the body's genes. A...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eEnglish/Nat\u003cbr/\u003eA new magic pill in medicine has been unveiled in New York City.\u003cbr/\u003eThis pill acts as a \"dimmer switch\" on the body's internal disease fighting system by adjusting the strength of the response to disease by the body's genes. \u003cbr/\u003eA report on the experimental study appears in the January First issue of \"Science.\"\u003cbr/\u003eIn a major advance for biotechnology, scientists have demonstrated the ability to not only introduce therapeutic genes into the body, but also precisely control their activity with a drug that can be given as a simple pill.\u003cbr/\u003eExperiments have been conducted on mice and monkeys.\u003cbr/\u003eThe Chief Executive Officer of the company that spearheaded the research and development efforts, Harvey J. Berger, said now gene therapy can be controlled like a \"dimmer-switch.\"\u003cbr/\u003eThis means a whole range of diseases, including diabetes and anaemia, will be easier to treat.\u003cbr/\u003eSOUNDBITE: (English)\u003cbr/\u003e\"What's important here, that this product, this set of discoveries, opens up new opportunities for gene therapy combining a new method of introducing the gene into the body by an injection, and a pill that allows one to regulate or control the way that gene works.  We've been able to create new opportunities for gene therapy, being able to approach diseases that were unapproachable with gene therapy in the past.\"\u003cbr/\u003eSUPER CAPTION:  Harvey J. Berger, Chairman \u0026amp; CEO, Ariad Pharmaceuticals\u003cbr/\u003eThe new method has some distinct advantages over current drug delivery systems.  \u003cbr/\u003eWith oral or injectable drugs, the patient experiences peaks and valleys in the amount of drug in the blood.\u003cbr/\u003eSide effects are often most severe during peaks and then the dosage drops to levels that may not provide therapeutic benefits.\u003cbr/\u003eSOUNDBITE: (English)\u003cbr/\u003e\"How does it work?  It's relatively simple. The patient would receive an injection, of the gene, the therapeutic gene, through simple injection.  Very much like the injection of penicillin or the injection of a vaccine.  And then the patient would take a pill, perhaps once a week, that would regulate or control the activity of that gene, and thus allow physicians to treat various diseases with an orally active therapy.\"\u003cbr/\u003eSUPER CAPTION:  Harvey J. Berger, Chairman and CEO,  Ariad Pharmaceuticals\u003cbr/\u003eSOUNDBITE: (English)\u003cbr/\u003e\"The first application that in fact we're actively involved in is the use of this to treat anaemia. To use the EPO gene under the regulation and the control of the pill that I just described. EPO regulates the production of red blood cells so when you receive EPO it stimulates the production of red blood cells, which is critical to the treatment of anaemia. And that has applications in patients with kidney failure, with AIDS, with cancer, among other diseases.\"\u003cbr/\u003eSUPER CAPTION:  Harvey J. Berger, Chairman and CEO, Ariad Pharmaceuticals\u003cbr/\u003eThe new treatment couples advances made at the University of Pennsylvania Medical Centre allowing the long-term introduction of genes into the body with a patented technology from Ariad Pharmaceuticals of Cambridge, Massachusetts, to regulate gene activity.\u003cbr/\u003eThe next phase of research, which will include clinical trials with human patients, is expected to begin in about twelve months.\u003cbr/\u003eNew York, New York, December 31, 1998\u003cbr/\u003e1.  Wide shot laboratory (file) pan to researcher at microscope\u003cbr/\u003e2.  Close up lab work (file)\u003cbr/\u003e3.  Wide shot Harvey J. Berger standing at computer\u003cbr/\u003e4.  SOUNDBITE: (English)  Harvey J. Berger, Chairman and CEO of Ariad\u003cbr/\u003e5.  Cutaway of hands\u003cbr/\u003e6.  SOUNDBITE:  (English) Harvey J. Berger, Chairman and CEO of Ariad\u003cbr/\u003e7.  Cutaway of how ARGENT gene therapy works\u003cbr/\u003e8.  SOUNDBITE:  (English) Harvey J. Berger, Chairman and CEO of Ariad\u003cbr/\u003e9.  Wide shot Harvey J. Berger at computer\u003cbr/\u003e10. Close up looking over Berger's shoulder\u003cbr/\u003e11. Close up screen of computer (graphics)\u003cbr/\u003e\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='action-container flex justify-between'\u003e\n\u003cbutton aria-expanded='false' aria-label='Read more description' class='rp-full-description' type='button'\u003e\n\u003ci class='fai fa-solid fa-align-left'\u003e\u003c/i\u003e\n\u003cspan id='read_more'\u003eRead More\u003c/span\u003e\n\u003c/button\u003e\n\u003cdiv class='rp-report'\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv aria-labelledby='resource-details-heading' class='rp-info-section'\u003e\n\u003ch2 class='title' id='resource-details-heading'\u003eResource Details\u003c/h2\u003e\n\u003cdiv class='rp-resource-details clearfix'\u003e\n\u003cdiv class='detail'\u003e\n\u003cdl\u003e\n\u003cdt\u003eCurator Rating\u003c/dt\u003e\n\u003cdd\u003e\u003cspan class=\"star-rating\" aria-label=\"3.5 out of 5 stars\" role=\"img\"\u003e\u003ci class=\"fa-solid fa-star text-action\" 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class='detail'\u003e\n\u003cdl\u003e\n\u003cdt\u003eDate\u003c/dt\u003e\n\u003cdd\u003e1998\u003c/dd\u003e\n\u003c/dl\u003e\n\u003c/div\u003e\n\u003cdiv class='detail'\u003e\n\u003cdl\u003e\n\u003ci aria-hidden='true' class='fai fa-solid fa-language'\u003e\u003c/i\u003e\n\n\u003c/dl\u003e\n\u003c/div\u003e\n\u003cdiv class='detail'\u003e\n\u003cdl\u003e\n\u003cdt\u003eAudiences\u003c/dt\u003e\u003cdd\u003e\u003cspan\u003e\u003ca href=\"/search?audience_ids%5B%5D=371079\u0026amp;grade_ids%5B%5D=259\u0026amp;search_tab_id=1\"\u003eFor Teacher Use\u003c/a\u003e\u003c/span\u003e\u003c/dd\u003e\u003cdd class=\"text-muted\"\u003e\u003ci class=\"fa-solid fa-lock mr5\"\u003e\u003c/i\u003e2 more...\u003c/dd\u003e\n\u003c/dl\u003e\n\u003c/div\u003e\n\u003cdiv class='detail'\u003e\n\u003cdl\u003e\n\n\u003c/dl\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv aria-labelledby='concepts-heading' class='rp-info-section'\u003e\n\u003ch2 class='title' id='concepts-heading'\u003eConcepts\u003c/h2\u003e\n\u003cdiv class='clearfix'\u003e\n\u003cdiv class='details-list concepts' data-identifier='Boclips::VideoDecorator' data-type='concepts'\u003eanemia, gene therapy, work, north america, biotechnology, business, diseases\u003c/div\u003e\n\u003cdiv class='concepts-toggle-buttons' data-identifier='Boclips::VideoDecorator'\u003e\n\u003cbutton aria-expanded='false' class='more btn-link' type='button'\u003e\n\u003cspan\u003eShow More\u003c/span\u003e\n\u003ci aria-hidden='true' class='fa-solid fa-caret-down ml5'\u003e\u003c/i\u003e\n\u003c/button\u003e\n\u003cbutton aria-expanded='true' class='less btn-link' style='display: none;' type='button'\u003e\n\u003cspan\u003eShow Less\u003c/span\u003e\n\u003ci aria-hidden='true' class='fa-solid fa-caret-up ml5'\u003e\u003c/i\u003e\n\u003c/button\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv aria-labelledby='additional-tags-heading' class='rp-info-section'\u003e\n\u003ch2 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