{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='Trials to determine correct dosage to protect people from H1N1 flu virus' data-url='/boclips/videos/5c54c0bed8eafeecae14d0e8' data-video-url='/boclips/videos/5c54c0bed8eafeecae14d0e8' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nTrials to determine correct dosage to protect people from H1N1 flu virus\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eBaltimore, Maryland - 10 August 20091. People entering building where flu vaccine study is being conducted2. Dr Wilbur Chen, from University of Maryland's Centre for Vaccine Development, looking at charts3. SOUNDBITE: (English) Dr Wilbur...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eBaltimore, Maryland - 10 August 2009\u003cbr/\u003e1. People entering building where flu vaccine study is being conducted\u003cbr/\u003e2. Dr Wilbur Chen, from University of Maryland's Centre for Vaccine Development, looking at charts\u003cbr/\u003e3. SOUNDBITE: (English) Dr Wilbur Chen, Centre for Vaccine Development - University of Maryland:\u003cbr/\u003e\"So this study is really trying to evaluate what are the optimal doses to get antibody responses for protection for individuals. And so, through this study we're going to be randomising people to either receive a 15 microgram dose or a 30 microgram dose. And, those doses are going to be separated by 21 days apart.\"\u003cbr/\u003e4. UPSOUND: (English) Dr. Wilbur Chen talking to Lorenzo Thornton, study participant:\u003cbr/\u003eChen: \"This is just the last step before you get vaccinated so what I'm simply going to do is basically go over your paperwork. But this is also your last opportunity to raise any questions or concerns about being in this study.\"\u003cbr/\u003eThornton: \"I have none.\"\u003cbr/\u003eChen: \"Okay good. It's an ongoing process.\"\u003cbr/\u003eThornton: \"Yes sir.\"  \u003cbr/\u003e5. Chen flipping through pages in notebook\u003cbr/\u003e6. UPSOUND: (English) Dr. Wilbur Chen talking to Lorenzo Thornton, study participant:\u003cbr/\u003eChen: \"Are you allergic to eggs or any components of the vaccine as far as you know?\"\u003cbr/\u003eThornton: \"No sir.\"\u003cbr/\u003eChen: \"Are you undergoing any form of immune suppression at this time, for cancer or anything?\"\u003cbr/\u003eThornton: \"No sir, not at all.\"\u003cbr/\u003eChen: \"Have you ever had a cancer before?\"\u003cbr/\u003eThornton: \"No sir.\"\u003cbr/\u003e7. Close-up of Chen's hand as he fills in form\u003cbr/\u003e8. Zoom in of nurse pulling vial of vaccine from box\u003cbr/\u003e9. Close-up of label on vial of vaccine\u003cbr/\u003e10. SOUNDBITE: (English) Linda Wadsworth, Paediatric Nurse - University of Maryland:\u003cbr/\u003e\"The process of immunising people has be done in a study so that we know if you're having any reactions and what what your immunogenicity is, which just tells you how much anti bodies you make from the vaccine. So, all this process is very important. We just can't put out medications or vaccines without going through the process.\"\u003cbr/\u003e11. Pull out from vaccine sign on wall to show woman sitting in examining room\u003cbr/\u003e12. Close-up of shoulder as injection is being given\u003cbr/\u003e13. Wide of central nurses station\u003cbr/\u003ePhiladelphia, Pennsylvania  - 7 August 2009\u003cbr/\u003e14. Exterior of MedImmune building\u003cbr/\u003e15. Close-up of printing process showing packaging\u003cbr/\u003e16. Employee in sterile protection suit\u003cbr/\u003e17. Process of empty vials being moved into machine\u003cbr/\u003e18. Vials being filled \u003cbr/\u003e19. Wide of sterile room where vials are filled\u003cbr/\u003e20. Syringes moving off assembly line\u003cbr/\u003eClinical trials for the H1N1 or swine flu vaccine began on Monday in several locations across the United States.\u003cbr/\u003eHundreds of Americans in eight cities line up for experimental swine flu shots in a race to get a vaccine out in case the new flu virus regains strength this fall and winter.\u003cbr/\u003eSeveral sites across the United States, including St. Louis, Missouri, Atlanta, Georgia, and the University of Iowa have been selected to participate in the study.\u003cbr/\u003eAbout 2,800 people will participate in the government-led studies. \u003cbr/\u003eAt the University of Maryland Medical School in Baltimore, Dr Wilbur Chen, Assistant Professor of Medicine at the Centre for Vaccine Development is in charge of a portion of the study.\u003cbr/\u003e\"This study is trying to evaluate what are the optimal doses to get antibody responses for protection for individuals,\" he added.\u003cbr/\u003eSome of the patients will receive one size dosage and another group will receive a double size dosage to determine which provides the maximum amount of protection, he said.\u003cbr/\u003eAfter receiving the inoculations, patients will be asked to keep a diary on how they feel.\u003cbr/\u003eThey also will receive two, four and six month checkups to monitor progress of the vaccine.\u003cbr/\u003eHealth officials expect to have about 160 million doses available in autumn, with the first batch sometime in\u003cbr/\u003eSeptember. \u003cbr/\u003eThe studies will test the safety and effectiveness of vaccines developed by drug makers and help determine dosage and whether it can be given with a seasonal flu shot.\u003cbr/\u003eParticipants will be given different combinations of two swine flu vaccines made by drug makers Sanofi Pasteur and CSL Limited and a seasonal flu vaccine.\u003cbr/\u003eThe clinical trial at the University of Maryland will be conducted in two sessions, 21 days apart.\u003cbr/\u003eScientists believe that two separate doses of the vaccine will be needed to prevent catching the flu during the winter.\u003cbr/\u003eLinda Wadsworth, a paediatric nurse, gave the first injection to patients in the Baltimore study.  \u003cbr/\u003eShe also has agreed to take part in the study and has received her first injection.\u003cbr/\u003e\"The process of immunising people has be done in a study so that we know if you're having any reactions and what what your immunogenicity is, which just tells you how much anti bodies you make from the vaccine,\" said Wadsworth.\u003cbr/\u003eForty nine participants were inoculated on Monday in Baltimore with another forty patients scheduled to be screened the next day.\u003cbr/\u003eThe vaccine has been shown to be effective in animals, but this is the first human test of the H1N1 vaccine.\u003cbr/\u003eHealth officials are haunted by the swine flu vaccine campaign in 1976, which was stopped after unexpectedly high numbers of patients suffered a 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