{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='New treatment to help patients with peanut allergy ++EMBARGOED++' data-url='/boclips/videos/5c54bfe7d8eafeecae146b23' data-video-url='/boclips/videos/5c54bfe7d8eafeecae146b23' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nNew treatment to help patients with peanut allergy ++EMBARGOED++\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eThis is definitely not something you should try at home if you suffer an allergic reaction to nuts, especially peanuts.Had Lena Barden done this when she was younger she would have suffered analphylaxis, her immune system would have gone...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eThis is definitely not something you should try at home if you suffer an allergic reaction to nuts, especially peanuts.\u003cbr/\u003eHad Lena Barden done this when she was younger she would have suffered analphylaxis, her immune system would have gone into overdrive and her life would have been at risk.\u003cbr/\u003eShe is one of 99 children who have taken part in a controlled trial at Addenbrookes Hospital in the UK.    \u003cbr/\u003eThe experimental therapy fed children with peanut allergies small amounts of peanut flour.\u003cbr/\u003eHer family didn't discover Lena Barden's susceptibility to peanuts until she was two years old.\u003cbr/\u003eShe suffered an initial shock after eating peanuts , and was taken to hospital.\u003cbr/\u003eDoctors warned her mother to expect another more severe reaction, with 24 hours.\u003cbr/\u003eDiana Barden reveals what happened next: \"She (Lena) started going into real anaphylactic shock, so her hands swelled up and her feet swelled up she was only two, and I sort of picked her up and she became floppy and lifeless and of course eventually her throat was swelling up and I realised she was struggling for breath.\"\u003cbr/\u003eSince then the Barden's discovered Lena had the same reaction to all tree nuts, and everyone took care not to allow anything into her diet which may contain any nut product.\u003cbr/\u003eLena Barden doesn't miss the peanuts themselves, she dislikes them intensely.\u003cbr/\u003eBut now she needs to take a specific quantity of them each day: \"I take my peanuts five a day. I don't enjoy it, but I've been told to stay away from most food labelling that still say contains peanuts, like whole peanuts, or something. I've been told to stay away from that and the other nuts because I'm still allergic to them.\"\u003cbr/\u003eAlthough the actual cause of nut allergies isn't known, researchers say people who have them come from families where allergies like eczema, asthma and others are more prevalent.\u003cbr/\u003eThat was not the case with the Bardens.\u003cbr/\u003eDiana Barden, whose mother is American, explains: \"I was weaned on peanut butter. I've eaten peanut butter since I was able to walk really, no my son has no allergies, no problems at all. So this was a huge surprise because we don't have any allergies, asthma, eczema, or anything in the family going back over history at all.\"\u003cbr/\u003eThis is the hospital laboratory where successive researchers have spent years calculating just how much of a dose of peanut flour to give to patients.\u003cbr/\u003eThe peanut flour had an amount of fat removed and different batches were checked to ensure patients always received exactly the same amount of the nut, and its protein, which causes allergic reactions.\u003cbr/\u003eToo much would put them at risk, too little would not train the body to have the right response.\u003cbr/\u003eThe study was run here by consultant Dr Andrew Clarke with paediatric allergist Pam Ewan.\u003cbr/\u003eHe says the study was different to others that have been conducted in the past because of the doses.\u003cbr/\u003eAll the doses were given under strict supervision at the hospital and the children were observed to ensure there weren't any worrying side effects; the most frequent were nausea and vomiting. \u003cbr/\u003eAfter six months of treatment, more than 80 percent of the children are now able to eat five peanuts regularly. \u003cbr/\u003eClark says:\"We've started with really tiny amounts that are so small that really no-one is likely to react to it and it's equivalent to about one-seventieth of a peanut. Now the child would take that every day for a couple of weeks and then we'd double the dose. So every two weeks for nine visits we would increase the dose by about doubling, so by the end of three, or four months, the child would then be effectively eating the equivalent of five peanuts a day.\"\u003cbr/\u003eAlthough doctors know the protein in peanuts causes harmful reactions, they haven't yet worked out why some children remain resistant to the treatment.\u003cbr/\u003eThey don't believe age or the severity of previous allergic reactions make a significant difference to whether the treatment was successful, or not among the boys and girls taking part.\u003cbr/\u003eThe team at the hospital say further research needs to be carried out, but they also insist that the data from the trial is so robust that they want the treatment to be made available to patients in the future.\u003cbr/\u003eThe team says any future treatment must be done under strict medical supervision by an allergist who has been trained to use oral immunotherapy at a hospital.\u003cbr/\u003eDr. Pam Ewan says: \"There are half a million people out there with peanut allergies so we would like to see this research  now being developed into a treatment and we'd like to see it out there as soon as possible. Exactly when that will be, I can't say.\"\u003cbr/\u003eThe hospital is hoping to be able to provide the treatment along with others at a special peanut allergy clinic at Addenbrookes Hospital.\u003cbr/\u003eClark says: \"Well I'd hesitate to call it a cure, but we've got them to the point where they can tolerate eating five peanuts a day and we've got most of them to the point where they can tolerate eating ten peanuts accidentally, so this is an amount that makes a huge difference to their lives. It improves their quality of life when you think beforehand that they would be checking every single label of everything they ate and also avoiding going out and eating in restaurants, it makes a massive difference to them.\"\u003cbr/\u003eThe Barden's though can't afford to relax, not least because they believe food labelling isn't precise enough.\u003cbr/\u003eCurrently according to Britain's Food Standards Authority: \"The rules for pre-packed foods establish a list of 14 food allergens, which have to be indicated by reference to the source allergen whenever they, or ingredients made from them, are used at any level in pre-packed foods, including alcoholic drinks. The list consists of cereals containing gluten, crustaceans, molluscs, eggs, fish, peanuts, nuts, soybeans, milk, celery, mustard, sesame, lupin and sulphur dioxide at levels above 10mg/kg, or 10 mg/litre, expressed as SO2.\"\u003cbr/\u003eBut it also adds: \"Some ingredients derived from the listed allergenic foods are so highly processed that they are no longer capable of triggering an adverse reaction.\"\u003cbr/\u003eThe Authority is concerned that manufacturers use warnings to often to protect themselves.\u003cbr/\u003eThe legislation governing labelling will change in December this year (2014).\u003cbr/\u003eLaws will require: \"businesses to provide allergy information on food sold unpackaged, in for example catering outlets, deli counters, bakeries and sandwich bars\". \u003cbr/\u003e\"There will also be changes to existing legislation on labelling allergenic ingredients in prepacked foods. Guidance is being developed to help businesses meet these new requirements\". \u003cbr/\u003eResponding to the medical trial Diana Barden says: \"It has allowed us to relax a bit, having said that Lena's still allergic to all the other tree nuts so I do still have to read labels, but, but, you know I can take a few more risks than, let's say a few years ago.\"\u003cbr/\u003eShe says: \"It'll never be normal by other people's standards but you do over time, I think you grow into what you have to grow into.\" \u003cbr/\u003eBut for twelve year old Lena Barden there is some comfort in being able, for the first time, to enjoy sharing some of her friend's bad eating habits.\u003cbr/\u003eShe says: \"Everyone around me was always boasting of eating chocolate and sweets and doughnuts and everything and I'd never tried a donut before I was about eleven, but I've had one now, yes because most of them say they contain peanuts, or something so I tried one like that I love them.\" \u003cbr/\u003eAccording to researchers at Addenbrookes there are about ten million people with peanut allergies worldwide. \u003cbr/\u003ePeople who go into anaphylactic shocks are treated with adrenalin.\u003cbr/\u003eThe Addenbrookes study is published in The Lancet medical journal (Thursday January 30, 2014).\u003cbr/\u003eCambridge, UK, January 28, 2014\u003cbr/\u003e1. Mid shot of twelve year old nut allergy patient Lena Barden pouring out a bag of peanuts \u003cbr/\u003e2. Close of peanuts in Barden's hands \u003cbr/\u003e3. Close of Lena Barden \u003cbr/\u003e4. Close tilt up from Barden's hands to face \u003cbr/\u003e5. Close of Lena Barden's mother Diana Barden cooking \u003cbr/\u003e6. Close of Lena Barden talking to mother \u003cbr/\u003e7. SOUNDBITE: (English), Diana Barden, mother of child with nut allergy \u003cbr/\u003e\"She started going into real anaphylactic shock, so her hands swelled up and her feet swelled up she was only two, and I sort of picked her up and she became very floppy and lifeless and of course eventually her throat was swelling up and I realised she was struggling for breath.\"\u003cbr/\u003e8. Close of egg being cracked into frying pan \u003cbr/\u003e9. Various of Diana Barden cooking \u003cbr/\u003e10. Close of Lena Barden listening to her mother \u003cbr/\u003e11. Close of eggs cooking \u003cbr/\u003e12. SOUNDBITE: (English), Lena Barden, patient on Cambridge peanut trial  \u003cbr/\u003e\"I take my peanuts five a day. I don't enjoy it, but I've been told to stay away from most food labelling that still say 'contains peanuts', like whole peanuts, or something. I've been told to stay away from that and the other nuts because I'm still allergic to them.\u003cbr/\u003e13. Close of Lena Barden talking to her mother \u003cbr/\u003e14. Close of Diana Barden dishing out eggs \u003cbr/\u003e15. Close pan of fried eggs on toast \u003cbr/\u003e16. Mid of mother preparing food and daughter laying table \u003cbr/\u003e17. Close low shot of Barden taking food to table \u003cbr/\u003e18. Mid of Bardens sitting down to eat \u003cbr/\u003e19. Close of daughter Lena Barden spreading button on bread\u003cbr/\u003e20. Close of Lena Barden \u003cbr/\u003e21. Close tilt up from plate to Lena Barden eating \u003cbr/\u003e22. Various of school photographs in frames showing Lena and her older brother Lawrence \u003cbr/\u003e23. SOUNDBITE: (English), Diana Barden, mother of child with nut allergy \u003cbr/\u003e\"I was weaned on peanut butter. I've eaten peanut butter since I was able to walk really, no my son has no allergies, no problems at all. So this was a huge surprise because we really don't have any allergies, asthma, eczema, or anything in the family going back over history at all.\"\u003cbr/\u003e24. Various of researcher in white coat measuring out peanut flour in laboratory at Addenbrooke's Hospital where trial was carried out \u003cbr/\u003e25. Close of Dr. Andrew Clark in Addenbrooke's laboratory \u003cbr/\u003e26. Mid of consultants Clark and Dr. Pam Ewan, paediatric allergist by scales holding a shovel of peanut flour \u003cbr/\u003e27. Close of Ewan picking up container holding peanut flour \u003cbr/\u003e28. Close of Clarke holding lab container labelled peanut flour \u003cbr/\u003e29. SOUNDBITE: (English), Dr. Andrew Clark, consultant, paediatric allergy, Cambridge University Hospitals, Addenbrookes \u003cbr/\u003e\"We've started with really tiny amounts that are so small that really no-one is likely to react to it and it's equivalent to about one-seventieth of a peanut. Now the child would take that every day for a couple of weeks, and then we'd double the dose. So every two weeks for nine visits we would increase the dose by about doubling, so by the end of three, or four months, the child would then be effectively eating the equivalent of five peanuts a day.\"\u003cbr/\u003e30. Close of Lena Barden talking and eating\u003cbr/\u003e31. Close of her mother Diana Barden eating and listening \u003cbr/\u003e32. Close of food on plate \u003cbr/\u003e33. Mid of Lena eating \u003cbr/\u003e34. Mid profile shot of Bardens eating supper \u003cbr/\u003e35. SOUNDBITE: (English), Dr. Pam Ewan, paediatric allergist, Addenbrookes Hospital \u003cbr/\u003e\"There are half a million people out there with peanut allergies so we would like to see this research now being developed into a treatment and we'd like to see it out there as soon as possible. But exactly when that will be, I can't say.\"\u003cbr/\u003e36. Close zoom out from peanut flour container to close rear view of Pam Ewan \u003cbr/\u003e37. Close of Ewan\u003cbr/\u003e38. Close of scales \u003cbr/\u003e39. SOUNDBITE: (English), Dr. Andrew Clark, consultant, paediatric allergy, Cambridge University Hospitals, Addenbrookes \u003cbr/\u003e\"Well I'd hesitate to call it a cure, but we've got them to the point where they can tolerate eating five peanuts a day and we've got most of them to the point where they can tolerate eating ten peanuts accidentally, so this is an amount that makes a huge difference to their lives. It improves their quality of life when you think beforehand that they would be checking every single label of everything they ate and also avoiding going out and eating in restaurants, it makes a massive difference to them.\"\u003cbr/\u003e40. Close of Lena Barden's plate with food \u003cbr/\u003e41. Close of Diana Barden listening to her daughter \u003cbr/\u003e42. SOUNDBITE: (English), Diana Barden, mother of child with nut allergy \u003cbr/\u003e\"It has allowed us to relax a bit, having said that Lena's still allergic to all the other tree nuts so I do still have to read labels, but, but, you know I can take a few more risks than, let's say a few years ago.\"\u003cbr/\u003e43. Close of Lena Barden\u003cbr/\u003e44. SOUNDBITE: (English), Diana Barden, mother of child with nut allergy \u003cbr/\u003e\"It'll never be normal by other people's standards but you do over time, I think you grow into what you have to grow into.\" \u003cbr/\u003e45. SOUNDBITE: (English), Lena Barden, patient on Cambridge peanut trial  \u003cbr/\u003e\"Everyone around me was always boasting of eating chocolate and sweets and doughnuts and everything and I'd never tried a donut before I was about eleven, but I've had one now, yes because most of them say they contain peanuts, or something so I tried one like that I love them.\" \u003cbr/\u003e46. 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id='additional-tags-heading'\u003eAdditional Tags\u003c/h2\u003e\n\u003cdiv class='clearfix'\u003e\n\u003cdiv class='details-list keyterms' data-identifier='Boclips::VideoDecorator' data-type='keyterms'\u003ehealth, write, back, makes, life, make, child, checking, eating, food allergies, stay, sort, medical research, skin disorders, dose, eczema, diagnosis and treatment, donut, started, point, amount, diseases and conditions, allergic, grow, people, line, told\u003c/div\u003e\n\u003cdiv class='keyterms-toggle-buttons' data-identifier='Boclips::VideoDecorator'\u003e\n\u003cbutton aria-expanded='false' class='more btn-link' type='button'\u003e\n\u003cspan\u003eShow More\u003c/span\u003e\n\u003ci aria-hidden='true' class='fa-solid fa-caret-down ml5'\u003e\u003c/i\u003e\n\u003c/button\u003e\n\u003cbutton aria-expanded='true' class='less btn-link' style='display: none;' type='button'\u003e\n\u003cspan\u003eShow Less\u003c/span\u003e\n\u003ci aria-hidden='true' class='fa-solid fa-caret-up ml5'\u003e\u003c/i\u003e\n\u003c/button\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv aria-labelledby='educator-ratings-heading' class='rp-info-section'\u003e\n\u003ch2 class='title sr-only' id='educator-ratings-heading'\u003eEducator Ratings\u003c/h2\u003e\n\u003cdiv id=\"educator-ratings-root\"\u003e\u003c/div\u003e\u003cdiv id=\"all-educator-ratings-root\"\u003e\u003c/div\u003e\u003cdiv id=\"educator-rating-form-root\"\u003e\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-resource'\u003e\n\u003cdiv aria-label='Show resource details' class='rp-show-info' role='button' tabindex='0'\u003e\n\u003ci class='fai fa-solid fa-align-left'\u003e\u003c/i\u003e\nShow resource details\n\u003c/div\u003e\n\u003cdiv aria-label='Video player' class='player' id='player-wrapper' role='region'\u003e\n\u003cdiv class='relative container mx-auto' id='lp-boclips-visitor-thumbnail'\u003e\n\u003ca class=\"block\" data-html=\"true\" data-placement=\"bottom\" data-trigger=\"click\" data-content=\"\u003cdiv class=\u0026quot;text-center py-2\u0026quot;\u003e\u003ca class=\u0026quot;bold\u0026quot; href=\u0026quot;/auth/users/sign_in\u0026quot;\u003eSign in\u003c/a\u003e or \u003ca class=\u0026quot;bold text-danger\u0026quot; data-posthog-event=\u0026quot;Signup: LP Signup Activity\u0026quot; data-posthog-location=\u0026quot;body_link_boclips\u0026quot; data-remote=\u0026quot;true\u0026quot; href=\u0026quot;/subscription/new\u0026quot;\u003eJoin Now\u003c/a\u003e\u003c/div\u003e\" data-title=\"Get Full Access\" data-container=\"body\" rel=\"popover\" tabindex=\"0\" aria-label=\"Play video: New treatment to help patients with peanut allergy ++EMBARGOED++\" href=\"/subscription/new\"\u003e\u003cimg class=\"resource-img img-thumbnail img-responsive z-10 lp-boclips-thumbnail w-full h-full lozad\" alt=\"New treatment to help patients with peanut allergy ++EMBARGOED++\" title=\"New treatment to help patients with peanut allergy ++EMBARGOED++\" onError=\"handleImageNotLoadedError(this)\" data-default-image=\"https://static.lp.lexp.cloud/images/attachment_defaults/resource/large/missing.png\" data-src=\"https://static.lp.lexp.cloud/images/attachment_defaults/resource/large/missing.png\" width=\"315\" height=\"220\" src=\"data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs\" /\u003e\n\u003cspan aria-hidden='true' class='flex justify-center items-center bg-white rounded-full w-16 h-16 absolute top-1/2 left-1/2 -mt-8 -ml-8 cursor-pointer z-0 border-2 border-primary drop-shadow-md lp-boclips-thumbnail-playBtn'\u003e\n\u003ci class='fa-solid fa-play text-primary text-3xl ml-1 drop-shadow-xl'\u003e\u003c/i\u003e\n\u003c/span\u003e\n\u003c/a\u003e\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n"}