{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-572d6a42.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-f4d0de30.css\" media=\"all\" /\u003e\n\u003cdiv data-title='Scientists complete a quarter of the first US biobank' data-url='/boclips/videos/5c54bf83d8eafeecae143bd3' data-video-url='/boclips/videos/5c54bf83d8eafeecae143bd3' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nScientists complete a quarter of the first US biobank\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eOakland, California, US, April 21, 20101. Low angle of lab technician2. Close up of saliva samples3. Close up of samples with small barcodes4. Wide of lab technician walking up to computer5. Close up of computer 6. Close up of samples...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eOakland, California, US, April 21, 2010\u003cbr/\u003e1. Low angle of lab technician\u003cbr/\u003e2. Close up of saliva samples\u003cbr/\u003e3. Close up of samples with small barcodes\u003cbr/\u003e4. Wide of lab technician walking up to computer\u003cbr/\u003e5. Close up of computer \u003cbr/\u003e6. Close up of samples being prepared to be sent to UCSF\u003cbr/\u003e7. Wide shot of Oakland skyline\u003cbr/\u003e2. Low angle of the exterior of Kaiser Permanente Division of Research building\u003cbr/\u003e3. Entrance to the lab\u003cbr/\u003e4. Mid shot of lab worker\u003cbr/\u003e5. Close up of lab equipment\u003cbr/\u003e6. Medium close shot of Cathy Schaefer with lab worker\u003cbr/\u003e7. SOUNDBITE: (English), Cathy Schaefer, Exec. Director, Research Program on Genes, Environment \u0026amp; Health (RPGEH)\u003cbr/\u003e\"The purpose of building a resource like this is really to speed up research, to bring the day closer when we'll have important and real information that can be shared that will make a difference in people's health.\"\u003cbr/\u003eSan Francisco, US, April 21, 2010\u003cbr/\u003e8. Mid shot of Neil Risch working on at a computer\u003cbr/\u003e9. Close up of Neil Risch's fingers on a keyboard\u003cbr/\u003e10. SOUNDBITE (English) Neil Risch, Director, UCSF Institute for Human Genetics\u003cbr/\u003e\"Never has this amount of genetic data been created on a resource like this where we have longitudinal information up to 20 years or longer on the majority of these individuals. Clinical information, pharmacy information, laboratory tests, radiology information - it's just unprecedented, the amount of data that can be examined looking for genetic and environmental correlates for all these traits and diseases as well as healthy ageing.\"\u003cbr/\u003e11. Technician taking samples out of a freezer\u003cbr/\u003e12. Close up of frozen samples\u003cbr/\u003e13. Tilt down of technician packing samples for UCSF with ice packs\u003cbr/\u003e14. Close up of samples with ice packs\u003cbr/\u003e15. Wide of Esther Hill walking through shot\u003cbr/\u003e16. SOUNDBITE: (English), Esther Hill, DNA volunteer\u003cbr/\u003e\"I received information from Kaiser asking if I would be part of this study and I was really interested in it. I have two children, two sons, and so I have a sort of  vested interest in research and medical discovery. I want things to be better for my kids. So that was the thing that made me most want to get involved in this study.\"\u003cbr/\u003e17. Low angle close up of UCSF sign\u003cbr/\u003e18. Dr. Pui Kwok working on a laptop\u003cbr/\u003e19. Close up of  Dr. Pui Kwok's typing on the laptop keyboard\u003cbr/\u003e20. SOUNDBITE: (English), Dr. Pui Kwok, Professor of Dermatology, UCSF\u003cbr/\u003e\"The diversity of the Northern California region where our cohort represents many different ethnic backgrounds and racial groups whereas most other countries because of their homogeneous populations, their bio-banks are quite kind of narrow in terms of ethnicity.\"\u003cbr/\u003e21. Lab technician checking samples at the UCSF-Kwok lab\u003cbr/\u003e22. Close up of samples in the DNA amplification area\u003cbr/\u003e23. SOUNDBITE: (English), Dr. Pui Kwok, Professor of Dermatology, UCSF\u003cbr/\u003e\"After the reagents (substance added to check for reaction) have been put together with the DNA, we're going to put it in an incubator that will amplify the DNA into millions of copies. And so the robot is going to pick up the plate and put it into the incubator.\"\u003cbr/\u003e24. Close up of robot putting a plate into an incubator\u003cbr/\u003e25. Close up of technician showing DNA samples\u003cbr/\u003e26. Close up of samples sliding into machine\u003cbr/\u003e27. Close up of container\u003cbr/\u003e28. Tilt up of a technician moving samples\u003cbr/\u003e29. Close up of technician putting samples into a centrifuge\u003cbr/\u003eBerkeley, California, US, April 27, 2010\u003cbr/\u003e30. Wide shot of entrance to Stanley Hall at the University of California, Berkeley\u003cbr/\u003e37. Close up of Professor Michael Eisen writing on a white board and speaking\u003cbr/\u003e38. Close up of Eisen's face in profile\u003cbr/\u003e39. Medium close of Michael Eisen writing and marking white board\u003cbr/\u003e40. SOUNDBITE: (English), Prof. Michael Eisen,  Genetics, Genomics and Development, University of California, Berkeley\u003cbr/\u003e\"Once you know, okay, my doctor knows my genotype so he can tell me which drugs I should be taking when I get sick or what types of conditions I might face downstream and how I can try to mitigate them. And once people are getting that benefit and once it starts to make their lives better, and make them healthier, I think that the fears that they have about this information getting our there, they won't disappear, but they'll be balanced by the good.\"\u003cbr/\u003eSan Francisco, California - April 21, 2010\u003cbr/\u003e41. Wide shot of San Francisco Bay\u003cbr/\u003eScientists have begun unlocking the secrets of the human genome using a database of genetic information they hope will eventually reveal the root of many serious diseases.\u003cbr/\u003eThe Californian study hopes to uncover why some us are more susceptible to certain illnesses and why some of us will live longer than others.\u003cbr/\u003eEach of these precious little packages could contribute to unlocking the secrets of diseases which continue to claim millions of lives around the world.\u003cbr/\u003eThese are just some of the 140,000 DNA samples collected from volunteers.\u003cbr/\u003eThey're being speedily processed using sophisticated robots and automated systems.\u003cbr/\u003eIt's all part of a $25 million dollar (USD) government funded project called the Research Program on Genes, Environment and Health (RPGEH).\u003cbr/\u003eThe programme's run by scientists at Kaiser Permanente, the country's largest non-profit organisation providing health care and hospital treatment along with geneticists from the University of California San Francisco.\u003cbr/\u003eKaiser Permanente collect the genetic information from a growing pool of volunteers from its patients.\u003cbr/\u003eCathy Schaefer is Executive Director of the gene research program.\u003cbr/\u003eShe says \"the purpose of building a resource like this is really to speed up research, to bring the day closer when we'll have important and real information that can be shared that will make a difference in people's health.\"\u003cbr/\u003eThey aim to have built up a biobank of genetic information based on the samples of half a million Californians by 2013. \u003cbr/\u003eThis will be combined with patient surveys and information from Kaiser's existing database which the National Institutes of Health believes is the world's largest civilian electronic health record.\u003cbr/\u003eWhen the laboratories here in Oakland have completed processing the saliva samples they're sent off to scientists at the University of California San Francisco, where another team will perform the genotyping, where they determine their genetic makeup. \u003cbr/\u003eUCSF's Director at the Institute for Human Genetics is Neil Risch.\u003cbr/\u003eRisch claims the amount of genetic data being collected here is impressive.\u003cbr/\u003eHe says \"clinical information, pharmacy information, laboratory tests, radiology information, it's just unprecedented, the amount of data that can be examined looking for genetic and environmental correlates for all these traits and diseases as well as healthy ageing.\"\u003cbr/\u003eAmong those contributing their DNA to the study is Esther Hill a mother with two children.\u003cbr/\u003eShe says because of this she feels she has \"a sort of  vested interest in research and medical discovery. I want things to be better for my kids. So that was the thing that made me most want to get involved in this study.\"\u003cbr/\u003eIn the past, the cost of genotyping this many samples would have been prohibitive, but technological improvements and the large number of samples has helped lower the cost.\u003cbr/\u003eEven so it still amounts to several hundred dollars per person.\u003cbr/\u003eUCSF's Professor of Dermatology, Dr. Pui Kwok, says one of the greatest benefits of the study is that it isn't dedicated to a single disease.\u003cbr/\u003eHe says it'll be more useful to the medical profession because of \"the diversity of the Northern California region where our cohort represents many different ethnic backgrounds and racial groups\".\u003cbr/\u003eAccording to Kwok \"most other countries because of their homogeneous populations, their bio-banks are quite kind of narrow in terms of ethnicity.\"\u003cbr/\u003eAlso the average age of volunteers is 65 which means the biobank created here will be especially useful when it comes to  focussing on aging and age-related diseases.\u003cbr/\u003eAnother scientist getting excited about the biobank is geneticist Michael Eisen - a passionate supporter of the Public Library of Science, as you can see from his sweatshirt.\u003cbr/\u003eHe's also an enthusiastic researcher into the fruit fly.\u003cbr/\u003eThere has been some concern about people's privacy - but Eisen brushes these aside.\u003cbr/\u003eHe insists the matter of privacy is trumped by the importance this information contains for medicine in the future.\u003cbr/\u003eAccording to Eisen when our doctors know our genotypes they'll be able to target and prescribe drugs precisely.  \u003cbr/\u003eWhat more he says doctors will be able to tell us what our bodies have in store for us years ahead so that we can take practical steps to alleviate their future effects.\u003cbr/\u003eEisen argues that \"once people are getting that benefit and once it starts to make their lives better, and make them healthier, I think that the fears that they have about this information getting our there, they won't disappear, but they'll be balanced\".\u003cbr/\u003eThis genetic database is not the only one in the world.\u003cbr/\u003eThe UK's Biobank already has the genetic samples of 485,257 people and is expected to announce the completion of the bank by the middle of July 2010.\u003cbr/\u003eChina has already completed one databank.  \u003cbr/\u003eHere on the west coast of America, scientists are hoping to follow suit.\u003cbr/\u003e\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='action-container flex justify-between'\u003e\n\u003cbutton aria-expanded='false' aria-label='Read more description' class='rp-full-description' type='button'\u003e\n\u003ci class='fai fa-solid fa-align-left'\u003e\u003c/i\u003e\n\u003cspan id='read_more'\u003eRead More\u003c/span\u003e\n\u003c/button\u003e\n\u003cdiv class='rp-report'\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv 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