{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-572d6a42.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-f4d0de30.css\" media=\"all\" /\u003e\n\u003cdiv data-title='NEWS FEATURE Scientists trying to develop new treatments to fight cancer' data-url='/boclips/videos/5c54bf73d8eafeecae1433f8' data-video-url='/boclips/videos/5c54bf73d8eafeecae1433f8' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nNEWS FEATURE Scientists trying to develop new treatments to fight cancer\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eLeuven - November 15, 2007 1. Wide exterior of Leuven University Hospital 2. Leuven University Hospital flag flying3. Professor Peter Carmeliet walking into laboratory 4. Laboratory technicians conducting tests 5. Close-up of tray with...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eLeuven - November 15, 2007 \u003cbr/\u003e1. Wide exterior of Leuven University Hospital \u003cbr/\u003e2. Leuven University Hospital flag flying\u003cbr/\u003e3. Professor Peter Carmeliet walking into laboratory \u003cbr/\u003e4. Laboratory technicians conducting tests \u003cbr/\u003e5. Close-up of tray with test tubes as technician conducts tests\u003cbr/\u003e6. Professor Peter Carmeliet speaking to laboratory assistant \u003cbr/\u003e7. SOUNDBITE: (English) Professor Peter Carmeliet, lead researcher: \u003cbr/\u003e\"There are a number of anti-cancer drugs that are targeting the blood vessels. And the idea is to starve the tumour from nutrition and from oxygen and you do that by inhibiting the growth of blood vessels, by inhibiting angio-genesis. Now most of the drugs currently available in the clinic are focused or targeted on one specific protein, it is called VEGF (Vascular endothelial growth factor). And what we have now discovered is that an antibody against another growth factor PLGF (placental growth factor) has actually complimentary mechanisms and can be combined together with VEGF inhibitors to treat cancer.\" \u003cbr/\u003e8. Various of laboratory assistants looking through microscope \u003cbr/\u003e9. Animation from Leuven University Hospital illustrating how the treatment works on tumour, UPSOUND: (English) Voice-over\u003cbr/\u003e\"Scientists have discovered that this process (referring to the tumour growth) can be blocked by the administration of a small molecule called anti-PLGF antibody. The antibody binds to the PLGF growth factor thereby preventing it from associating with the capillary vessel. This effectively blocks the expansion of the capillary network and tumour growth is slowed because of limited blood supply. Because of the strong positive effect of the anti-PLGF antibody the cancer killing cells of the immune system can now work faster than the rate of the cancer cell division, resulting in a marked reduction in tumour size.\" \u003cbr/\u003e10. SOUNDBITE: (English) Professor Peter Carmeliet, lead researcher: \u003cbr/\u003e\"We can think about two new opportunities. The first one would be that we combine it in addition to existing anti-angiogenic agents, such as VEGF inhibitors. And we can increase the efficacy without increasing or aggravating the toxicity. And the second opportunity, is that we now can start to think about administering anti-PLGF for or to patients who could not receive actually, VEGF inhibitors, such as pregnant women with cancer or children with cancer or patients with too many side effects.\" \u003cbr/\u003e11. Transparent plastic container with laboratory mice \u003cbr/\u003e12. Professor Carmeliet explaining the work of the research physician as she injects laboratory mice with anti-PLGF, UPSOUND: (English) \"What Sonia is doing now is injecting the antibody against PLGF in mice in which she transplanted some tumour cells, some leukaemia cells, so that we can analyse then what the effect is really for the treatment of these cancers in the mice.\" \u003cbr/\u003e13. Close-up of laboratory mouse being injected with anti-PLGF \u003cbr/\u003e14. Cancer patient speaking to her oncologist in the lobby of Leuven University Hospital \u003cbr/\u003e15. Close-up sign reading: (Dutch) \"Oncology day care centre\"\u003cbr/\u003e16. SOUNDBITE: (Dutch) Mia Demeersseman, Patient with metastasised breast cancer: \u003cbr/\u003e\"If I have the possibility to convert it (referring to the cancer) into a chronic illness rather than a terminal illness and I know that scientist are continuing to find new ways to treat cancer, than maybe I have a chance in the long run to participate in a study, maybe not this one, but another study. I may have the opportunity to participate in a treatment that may lead to my possible cure. And that is something I continue to look forward to.\" \u003cbr/\u003e17. Cancer patient leaving hospital \u003cbr/\u003eBrussels - November 22, 2007 \u003cbr/\u003e18. Exterior of the Belgian Federal Anti-Cancer Foundation\u003cbr/\u003e19. Close-up sign, reading: (French and Dutch) \"Anti-Cancer Foundation\" \u003cbr/\u003e20. Researcher Patricia Servais from the Anti-Cancer Foundation moving banner \u003cbr/\u003e21. Close-up banner reading: \"Cancerphone\" \u003cbr/\u003e22. SOUNDBITE: (French) Patricia Servais, Chief researcher at the Belgian Federal Anti-Cancer Foundation: \u003cbr/\u003e\"Carmeliet's results are very positive and encouraging but we should not think this will be a miracle cure. The anti-angiogenesis and anti-PLGF treatments being developed by Carmeliet reveal very positive results; but these results are still from tests conducted on animals. So we are not yet at the stage of humans. Clinical studies will start at the end of this year.\" \u003cbr/\u003e23. Wide exterior of the anti-cancer foundation\u003cbr/\u003eIn the global fight against cancer, some of the world's top scientists are making encouraging noises as they try to develop new treatments against this terminal disease. \u003cbr/\u003eOne of the numerous studies attempting to turn the tide against cancer is research being conducted in Belgium at Leuven University Hospital, which according to the medical journal Cell has yielded very promising results. \u003cbr/\u003eProfessor Peter Carmeliet, head of the transgene technology and gene therapy department at Leuven University Hospital, leads the anti-cancer research.\u003cbr/\u003eThe research is based on a relatively new field of cancer medicine that focuses on proteins that can cut off the blood supply that tumours require to grow. \u003cbr/\u003eCarmeliet's anti-angiogenesis therapy aims to stop the growth of new blood vessels in tumours with the goal of stopping the tumour from growing and eventually destroying it. \u003cbr/\u003eCarmeliet accepts that the research is not the first to achieve positive results with anti-angiogenesis treatment, but he told AP Television that \"most of the drugs currently available in the clinic are focused or targeted on one specific protein, it is called VEGF (Vascular endothelial growth factor).\"\u003cbr/\u003e\"What we have now discovered is that an antibody against another growth factor PLGF (placental growth factor) has actually complimentary mechanisms and can be combined together with VEGF inhibitors to treat cancer,\" he added. \u003cbr/\u003eThe pre-clinical animal study conducted jointly by the Leuven University research team and biotech company ThromboGenics revealed a new anti-angiogenesis agent based on an antibody against the Placental Growth Factor (PLGF), also known as anti-PLGF. \u003cbr/\u003eAccording to Carmeliet, anti-PLGF heralds a breakthrough for the development of a new cancer therapy and the opportunities for new treatments.\u003cbr/\u003e\"The first one would be that we combine it in addition to existing anti-angiogenic agents, such as VEGF inhibitors. And we can increase the efficacy without increasing or aggravating the toxicity,\" he said.\u003cbr/\u003e\"And the second opportunity, is that we now can start to think about administering anti-PLGF for or to patients who could not receive actually, VEGF inhibitors, such as pregnant women with cancer or children with cancer or patients with too many side effects,\" he added.\u003cbr/\u003eA common complaint among cancer patients are the toxic side effects of traditional radiation and chemotherapy treatment. \u003cbr/\u003eMia Demeersseman who is an advanced metastasised breast cancer patient was encouraged by the research.\u003cbr/\u003e\"If I have the possibility to convert it (referring to the cancer) into a chronic illness rather than a terminal illness and I know that scientist are continuing to find new ways to treat cancer, than maybe I have a chance in the long run to participate in a study, maybe not this one, but another study,\" she said.\u003cbr/\u003eHowever, chief researcher at the Belgian Federal Anti-Cancer Foundation, Patricia Servais warned against people thinking the findings may represent a \"miracle cure.\"\u003cbr/\u003e\"The anti-angiogenesis and anti-PLGF treatments being developed by Carmeliet reveal very positive results but these results are still from tests conducted on animals. 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