{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='Sanofi and health official on Thai vaccine trial findings' data-url='/boclips/videos/5c54be23d8eafeecae1395a7' data-video-url='/boclips/videos/5c54be23d8eafeecae1395a7' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nSanofi and health official on Thai vaccine trial findings\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003e1. Wide of scientists and Sanofi-Pasteur's senior managers arriving on stage for news conference 2. Pan from journalists to Sanofi-Pasteur senior managers on stage 3. SOUNDBITE (French) Christopher Viehbacher, Chief Executive Officer,...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003e1. Wide of scientists and Sanofi-Pasteur's senior managers arriving on stage for news conference \u003cbr/\u003e2. Pan from journalists to Sanofi-Pasteur senior managers on stage \u003cbr/\u003e3. SOUNDBITE (French) Christopher Viehbacher, Chief Executive Officer, Sanofi-Aventis:\u003cbr/\u003e\"These are results that are statistically significant. That means, there is something and for the first time in a long time, that raised questions and that is important because questions show a new path for scientists to explore. So, for me, the first message is that I hope that we will now find a new dynamic, a new motivation for those who are working on researching this vaccine.\" \u003cbr/\u003e4. Mid of journalists listening to presentation of results announced by Sanofi-Aventis \u003cbr/\u003e5. Side shot of Sanofi-Pasteur's senior managers on stage addressing journalists \u003cbr/\u003e6. SOUNDBITE (French) Jean-Francois Delfraissy, Head of France's National AIDS Research Agency (ANRS): \u003cbr/\u003e\"These results are modest, what this means, especially for the larger public that as of today we do not have a vaccine against AIDS. We do not have a vaccine against AIDS. This vaccine will not be available on a large scale to the public.\"\u003cbr/\u003e7. Wide of journalists listening to presentation of results announced by Sanofi-Aventis \u003cbr/\u003e8. SOUNDBITES (French) Jean-Francois Delfraissy, head of France's National AIDS Research Agency (ANRS):\u003cbr/\u003e\"The conclusions that we must draw (from the results) is that this light of hope shows finally that it is possible to protect. And so if it is possible to protect, it means that we can do better and we must do better. So, there must be around this, a reflection of fundamental science, the construction of new vaccinal tools, both by the scientific and academic community but with a close partnership with large (pharmaceutical) companies. I hope that a certain number of companies are going to come back to research and to re-invest in the search for the vaccine against AIDS.\"\u003cbr/\u003e9. Wide of news conference\u003cbr/\u003eResearchers in Thailand on Thursday announced that for the first time, an experimental vaccine prevented infection with the AIDS virus - a surprising result and a watershed event in the battle against the deadly epidemic. \u003cbr/\u003eRecent failures had led many scientists to think such a vaccine might never be possible.\u003cbr/\u003ePresenting the findings of the world's largest AIDS vaccine trial of more than 16-thousand volunteers in Thailand, researchers said that a combination of two previously unsuccessful vaccines cut the risk of becoming infected with HIV by more than 31 percent.\u003cbr/\u003eThe trial - conducted by Thailand's Ministry of Public Health and sponsored in part by the US army - tested a two-vaccine combo in a \"prime-boost\" approach, where the first one primes the immune system to attack HIV and the second one strengthens the response.\u003cbr/\u003eThe study used strains of HIV common in Thailand and whether such a vaccine would work against other strains in the US, Africa or elsewhere in the world remained unknown, the scientists stressed.\u003cbr/\u003eBut the Thai health minister told reporters on Thursday that the findings were \"an important step,\" and the US ambassador to Thailand said the development brought scientists \"one step closer to an HIV vaccine.\"\u003cbr/\u003eEven a marginally helpful vaccine could have a big impact. \u003cbr/\u003eEvery day, seven and a half thousand people worldwide are newly infected with HIV and two (m) million died of AIDS in 2007, the United Nations agency UNAIDS estimates.\u003cbr/\u003eThe vaccines used in the trial were ALVAC from Sanofi Pasteur, the vaccine division of French drugmaker Sanofi-Aventis, and AIDSVAX, originally developed by VaxGen and now held by Global Solutions for Infectious Diseases, a nonprofit group founded by some former VaxGen employees.\u003cbr/\u003eALVAC uses canarypox, a bird virus altered so it can't cause human disease, to ferry synthetic versions of three HIV genes into the body.\u003cbr/\u003eAIDSVAX contains a genetically engineered version of a protein on HIV's surface. \u003cbr/\u003eThe vaccines are not made from whole virus - dead or alive - and cannot cause HIV.\u003cbr/\u003eSpeaking during a news conference in Paris on Thursday, Christopher Viehbacher, Sanofi-Aventis Chief Executive Officer praised the finding and said he hoped questions raised from the results would provide a \"new path for scientists to explore.\"\u003cbr/\u003eHowever Jean-Francois Delfraissy, Head of France's National AIDS Research Agency (ANRS) warned against reading too much into the results.\u003cbr/\u003e\"These results are modest...We do not have a vaccine against AIDS,\" he said.\u003cbr/\u003eBut Delfraissy said the results do show it is now \"possible to protect.\"\u003cbr/\u003e\"So if it is possible to protect, it means that we can do better and we must do better,\" he told journalists in Paris.\u003cbr/\u003eDelfraissy said he hopes research companies will now \"re-invest in the search for the vaccine against AIDS.\"\u003cbr/\u003eNeither vaccine in the study prevented HIV infection when tested individually in earlier trials and dozens of scientists had called the combination one futile when it began in 2003 - but the results proved the sceptics wrong.\u003cbr/\u003eThe study, which was also sponsored by the US National Institute of Allergy and Infectious Diseases, tested the combo in HIV-negative Thai men and women ages 18 to 30 at average risk of becoming infected. \u003cbr/\u003eHalf received four \"priming\" doses of ALVAC and two \"boost\" doses of AIDSVAX over six months. \u003cbr/\u003eThe others received dummy shots. No one knew who got what until the study ended.\u003cbr/\u003eAll participants were given condoms, counselling and treatment for any sexually transmitted infections and were tested every six months for HIV. \u003cbr/\u003eAny who became infected were given free treatment with antiviral medicines.\u003cbr/\u003eParticipants were followed for three years after vaccination ended.\u003cbr/\u003eResults: New infections occurred in 51 of the eight thousand and 197 given vaccine and in 74 of the eight thousand and 198 who received dummy shots. \u003cbr/\u003eThat worked out to a 31 percent lower risk of infection for the vaccine group.\u003cbr/\u003eThe vaccine had no effect on levels of HIV in the blood of those who did become infected. \u003cbr/\u003eThat had been another goal of the study, seeing whether the vaccine could limit damage to the immune system and help keep infected people from developing full-blown AIDS.\u003cbr/\u003eThe study was done in Thailand because US army scientists did pivotal research in that country when the AIDS epidemic emerged there, isolating\u003cbr/\u003evirus strains and providing genetic information on them to vaccine makers.\u003cbr/\u003eIt is unclear whether vaccine makers will seek to license the two-vaccine combo in Thailand based on the findings announced on Thursday. \u003cbr/\u003eBefore the trial began, the US Food and Drug Administration said other studies would be needed before the vaccine could be considered for US licensing.\u003cbr/\u003eAlso unclear was whether the Thai volunteers who received dummy shots would now be offered the vaccine. \u003cbr/\u003eResearchers had said they would do so if the vaccine showed clear benefit, defined as reducing the risk of infection by at least 50 percent.\u003cbr/\u003eScientists still want to know how long protection will last, whether booster shots will be needed and whether the vaccine helps prevent infection in gay men and injection drug users, since it was tested mostly in heterosexuals in the Thai trial.\u003cbr/\u003eDetails of the 105 (m) million US dollars study will be given at a vaccine conference in Paris in October.\u003cbr/\u003eIt was the third big vaccine trial since 1983, when HIV was identified as the cause of AIDS. \u003cbr/\u003eIn 2007, Merck \u0026amp; Co. stopped a study of its experimental vaccine after seeing it did not prevent HIV infection. \u003cbr/\u003eLater analysis suggested the vaccine might even raise the risk of infection in certain men. \u003cbr/\u003eThe vaccine itself did not cause infection.\u003cbr/\u003eIn 2003, AIDSVAX flunked two large trials, the first late-stage tests of any AIDS vaccine at the time.\u003cbr/\u003e\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='action-container flex justify-between'\u003e\n\u003cbutton aria-expanded='false' aria-label='Read more description' class='rp-full-description' type='button'\u003e\n\u003ci class='fai fa-solid fa-align-left'\u003e\u003c/i\u003e\n\u003cspan 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