{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='New research found testing bits of fetal DNA in a pregnant woman\u0026#39;s blood is more accurate than current methods of screening for Down Syndrome and other common disorders. The DNA tests may reduce false positives and unneeded invasive tests. (Feb. 26)' data-url='/boclips/videos/5c54bcb7d8eafeecae12ebb8' data-video-url='/boclips/videos/5c54bcb7d8eafeecae12ebb8' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nNew research found testing bits of fetal DNA in a pregnant woman\u0026#39;s blood is more accurate than current methods of screening for Down Syndrome and other common disorders. The DNA tests may reduce false positives and unneeded invasive tests. (Feb. 26)\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003eA DNA test of a pregnant woman's blood is more accurate than current methods of screening for Down syndrome and other common disorders, new research finds.If other studies bear this out, it could transform prenatal care by giving a more...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003eA DNA test of a pregnant woman's blood is more accurate than current methods of screening for Down syndrome and other common disorders, new research finds.\u003cbr/\u003eIf other studies bear this out, it could transform prenatal care by giving a more reliable, non-invasive way to detect these problems very early in pregnancy.\u003cbr/\u003eThat would let couples decide sooner whether to have an abortion or to prepare for a major medical problem. \u003cbr/\u003eIt also might cut down on the 200,000 more invasive tests like amniocentesis done each year in the United States to diagnose or rule out problems with a fetus.\u003cbr/\u003e\"The fetal DNA test is offered from ten weeks onwards,\" said the study leader, Dr. Diana Bianchi, of Tufts Medical Center in Boston.  \u003cbr/\u003eThat's a couple weeks sooner than current methods, and Bianchi says, \"it will help a woman get information about whether or not her pregnancy is at risk.\"\u003cbr/\u003eSeveral companies already sell these DNA blood tests.\u003cbr/\u003eThey screen for disorders caused by extra or missing chromosomes, such as Down syndrome, which occurs in about one of every 700 pregnancies.\u003cbr/\u003eCurrent screening methods are imprecise.\u003cbr/\u003eUltrasounds and various blood tests can hint at a problem but don't directly test for one.\u003cbr/\u003eThe next step is diagnostic testing _ amniocentesis, like a needle biopsy to collect fetal cells, or chorionic villus sampling, which takes a snip of the placenta. \u003cbr/\u003eBoth bring a small risk of miscarriage.\u003cbr/\u003eThe DNA tests aim to improve screening and lower the number of women referred for these more invasive tests. \u003cbr/\u003e\"There is a much lower false positive rate with the DNA tests,\" said Bianchi.\u003cbr/\u003eUsing a sample of the mom's blood, they sequence the alphabet of bits of DNA shed from the placenta and map them to various chromosomes. \u003cbr/\u003eThe numbers are compared to what's normal at that stage of pregnancy.\u003cbr/\u003eGroups like the American College of Obstetricians and Gynecologists say these DNA tests can be an option for higher risk pregnancies _ moms 35 and older, those with an abnormal ultrasound or blood test, or with a prior pregnancy involving abnormal chromosomes.\u003cbr/\u003eThe new study, published Wednesday by the New England Journal of Medicine, is the first to look at their use in a general U.S. population. \u003cbr/\u003eNearly 2,000 women had standard prenatal screening plus a fetal DNA test from Illumina Inc., a California company that sponsored the study.\u003cbr/\u003eBoth methods detected eight chromosome abnormalities, including five of Down syndrome. \u003cbr/\u003eBut the false alarm rate for Down syndrome with DNA testing was just a fraction of that for standard screening _ 0.3 percent versus 3.6 percent. \u003cbr/\u003eDNA tests also gave fewer false alarms for Edwards and Patau syndromes, less common chromosome abnormalities. \u003cbr/\u003eThat means far fewer women would be advised to get diagnostic tests to rule out a problem. \u003cbr/\u003e\"So the overwhelming majority of these women are told they do not have a fetus with a chromosome abnormality and therefore they achieve peace of mind as early at ten weeks into the pregnancy,\" said Bianchi.\u003cbr/\u003eBoston - February 26, 2014\u003cbr/\u003e1. Wide of researcher at her desk\u003cbr/\u003e2. SOUNDBITE:  (English) Dr. Diana Bianchi, Study Leader, Tufts Medical Center:\u003cbr/\u003e\"The fetal DNA test is offered from ten weeks onwards, from ten weeks any time up until delivery.  It will help a woman get information about whether or not her pregnancy is at risk for one of the major fetal chromosomal abnormalities.\"\u003cbr/\u003e3. Reverse shot of Bianchi at her desk\u003cbr/\u003e4. Tight of Bianchi writing\u003cbr/\u003e5. SOUNDBITE:  (English) Dr. Diana Bianchi, Study Leader, Tufts Medical Center:\u003cbr/\u003e\"It is a blood test.  It's a relatively small amount, a couple of teaspoons of blood, and in that blood sample there is DNA, meaning fragments of a DNA molecule, floating in the blood of the pregnant woman.\"\u003cbr/\u003e6. Mid of Bianchi at her computer\u003cbr/\u003e7. Bianchi showing how test progresses - DNA isolated from mother and fetus, DNA mapped out, chromosomes counted \u003cbr/\u003e8. SOUNDBITE:  (English) Dr. Diana Bianchi, Study Leader, Tufts Medical Center:\u003cbr/\u003e\"The newer DNA tests are more predictive, plus there is a much lower false positive rate with the DNA tests. So the current standard of care gives an approximately 3.6% false positive rate as opposed to 0.3% with the DNA test.\"\u003cbr/\u003e9. Various of equipment and materials in Bianchi's lab\u003cbr/\u003e10. SOUNDBITE:  (English) Dr. Diana Bianchi, Study Leader, Tufts Medical Center:\u003cbr/\u003e\"The great majority of pregnant women, especially the low-risk general obstetrical population who were the focus of this study have a very low risk of having a fetus with a chromosome problem.  So the overwhelming majority of these women are told they do not have a fetus with a chromosome abnormality and therefore they achieve peace of mind as early at ten weeks into the pregnancy. So, not only are they reassured, but they are not falsely alarmed that there is a screen test that's positive, and they are not sent further onwards to meet with a genetic counselor or have an invasive procedure.\"\u003cbr/\u003e11. 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