{"page":"\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/resources-c03aa079.css\" /\u003e\n\u003clink rel=\"stylesheet\" href=\"https://lessonplanet.com/assets/packs/css/lp_boclips_stylesheets-517835be.css\" media=\"all\" /\u003e\n\u003cdiv data-title='Spanish researchers test HIV vaccine' data-url='/boclips/videos/5c54bbf6d8eafeecae129108' data-video-url='/boclips/videos/5c54bbf6d8eafeecae129108' id='bo_player_modal'\u003e\n\u003cdiv class='boclips-resource-page modal-dialog panel-container'\u003e\n\u003cdiv class='react-notifications-root'\u003e\u003c/div\u003e\n\u003cdiv class='rp-header'\u003e\n\u003cdiv class='rp-type'\u003e\n\u003ci aria-hidden='true' class='fai fa-regular fa-circle-play'\u003e\u003c/i\u003e\nVideo\n\u003c/div\u003e\n\u003ch1 class='rp-title' id='video-title'\u003e\nSpanish researchers test HIV vaccine\n\u003c/h1\u003e\n\u003cdiv class='rp-actions'\u003e\n\u003cdiv class='mr-1'\u003e\n\u003ca class=\"btn btn-success\" data-posthog-event=\"Signup: LP Signup Activity\" data-posthog-location=\"body_link_boclips\" data-remote=\"true\" href=\"/subscription/new\"\u003e\u003cspan\u003e\u003cspan\u003eGet Free Access\u003c/span\u003e\u003cspan class=\"\"\u003e for 10 Days\u003c/span\u003e\u003cspan\u003e!\u003c/span\u003e\u003c/span\u003e\u003c/a\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-body'\u003e\n\u003cdiv class='rp-info'\u003e\n\u003cdiv aria-label='Hide resource details' class='rp-hide-info' role='button' tabindex='0'\u003e\u0026times;\u003c/div\u003e\n\u003ci aria-label='Expand resource details' class='rp-expand-info fai fa-solid fa-up-right-and-down-left-from-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003ci aria-label='Compress resource details' class='rp-compress-info fai fa-solid fa-down-left-and-up-right-to-center' role='button' tabindex='0'\u003e\u003c/i\u003e\n\u003cdiv class='rp-rating'\u003e\n\u003cspan class='resource-pool'\u003e\n\u003cspan class='pool-label'\u003ePublisher:\u003c/span\u003e\n\u003cspan class='pool-name'\u003e\n\u003cspan class='text'\u003e\u003ca data-publisher-id=\"30356011\" href=\"/search?publisher_ids%5B%5D=30356011\"\u003eCurated Video\u003c/a\u003e\u003c/span\u003e\n\u003c/span\u003e\n\u003c/span\u003e\n\u003c/div\u003e\n\u003cdiv class='rp-description'\u003e\n\u003cspan class='short-description'\u003e1. Various Hospital exteriors2. Various of patients getting trial vaccine3. Dr. Josep Maria Gatell, Infectious Diseases, Clinic Hospital4. SOUNDBITE: (Spanish) Dr. Josep Maria Gatell, Infectious Diseases, Clinic Hospital\"The goal of a...\u003c/span\u003e\n\u003cspan class='full-description hide'\u003e1. Various Hospital exteriors\u003cbr/\u003e2. Various of patients getting trial vaccine\u003cbr/\u003e3. Dr. Josep Maria Gatell, Infectious Diseases, Clinic Hospital\u003cbr/\u003e4. SOUNDBITE: (Spanish) Dr. Josep Maria Gatell, Infectious Diseases, Clinic Hospital\u003cbr/\u003e\"The goal of a therapeutic vaccine is to get to a stage where a patient will not have to take medication for the rest of their lives. After a few years or even months of drug therapy, the body could develop its own vaccine to fight the virus for itself. For that we have to stimulate his or her immune system. That is the goal.\"\u003cbr/\u003e5. Various laboratory\u003cbr/\u003e6. Scientists handling dendritic cells \u003cbr/\u003e7. Scientist introducing dendritic cells in cultivation device\u003cbr/\u003e8. Scientist observing denditric cells in microscope\u003cbr/\u003e9. Tilt of microscope\u003cbr/\u003e10. SOUNDBITE: (Spanish) Teresa Gallart, Head of vaccine project\u003cbr/\u003e\"Dendritic cells are cells that run through our body to collect virus and other pathogens to present them before lymphocytes and other defence cells to teach them to attack the invaders. They are sentinels, a sort of front line of defence.\"\u003cbr/\u003e11. Various of machine which detects immune response to HIV\u003cbr/\u003e12. SOUNDBITE: (Spanish) Teresa Gallart, head of vaccine project\u003cbr/\u003e\"The vaccine is based on the patient's own denditric cells from the blood as well as the patient's own virus. So the vaccine is personal and it requires a medical centre to develop it. We still have to find easier ways to produce it by using dendritic cells and viruses other than those from the patient and make them work.\"\u003cbr/\u003e13. Various shots of mass produced vaccine at pharmaceutical factory\u003cbr/\u003e14. SOUNDBITE: (Spanish) Dr. Josep Maria Gatell, Infectious Diseases, Clinic Hospital\u003cbr/\u003e\"We have proved that a therapeutic vaccine is possible. Having said that, for all therapeutic vaccines, they all are in early stages. We think that maybe in three or four years time they could become a reality in the fight for this disease.\"\u003cbr/\u003e15. Various of patients getting trial vaccine\u003cbr/\u003eAccording to United Nations statistics, there were close to five million new HIV infections worldwide in 2005. \u003cbr/\u003eIn the same year, 3 million people died of AIDS-related diseases.\u003cbr/\u003eToday the total number of people living with HIV stands at 40.3 million, double the number in 1995. \u003cbr/\u003eEven though a vaccine has so far been elusive, around the world scientists and medical researchers are racing to find effective treatments.  \u003cbr/\u003eIn Barcelona, Spain, researchers are working on a therapeutic approach to help the immune systems of infected people build resistance to the HIV virus and thus delay the patient's progression towards full blown AIDS.\u003cbr/\u003eThe Hospital Clinic in Barcelona, is said to be one of the world's leading institutions in the fight against HIV and AIDS.\u003cbr/\u003eA team of medical researchers in the Infectious Diseases Department is currently working on developing a therapeutic vaccine - for people already infected with the HIV virus.\u003cbr/\u003eIt is hoped the vaccine will stimulate the patient's own antibody production or cellular immunity, thus delaying the onset of full-blown AIDS. \u003cbr/\u003eThe team is lead by AIDS and HIV specialist, Dr. Josep Maria Gatell.\u003cbr/\u003eSOUNDBITE: (Spanish)\u003cbr/\u003e\"The goal of a therapeutic vaccine is to get to a stage where a patient will not have to take medication for the rest of their lives. After a few years or even months of drug therapy, the body could develop its own vaccine to fight the virus for itself. For that we have to stimulate his or her immune system. That is the goal.\"\u003cbr/\u003eSUPER CAPTION: Dr. Josep Maria Gatell, Infectious Diseases, Hospital Clinic de Barcelona\u003cbr/\u003eThe introduction of anti-retroviral therapies in the 1990s has helped transform HIV-AIDS from a death sentence to a chronic illness, at least in the developed world where drugs and treatment are both readily available.\u003cbr/\u003eToday, research in both the private and public sector is centered around two different approaches. One is preventive: it's aim to help people avoid getting the virus in the first place. The other is therapeutic: to help control the virus inside the body.\u003cbr/\u003eHIV infects cells of the immune system and destroys or impairs their function, leading to \"immune deficiency,\" which is when the body can no longer fight off infection and disease. \u003cbr/\u003eIn the trial taking place in Barcelona, patients are treated with dendritic cells which have been successful in treating skin melanomas and other aggressive forms of cancer.\u003cbr/\u003eSOUNDBITE: (Spanish)\u003cbr/\u003e\"Dendritic cells are cells that run through our body to collect virus and other pathogens to present them before lymphocyte and other defence cells to teach them to attack the invaders. They are sentinels, a sort of front line of defence.\"\u003cbr/\u003eSUPER CAPTION: Teresa Gallart, head of vaccine project\u003cbr/\u003eThe initial results show promise. \u003cbr/\u003eIn the first group of thirty patients treated with the vaccine, one quarter of them showed virus replication reduced by seven to nine times - with few side effects.\u003cbr/\u003eAnd the immune response from the defence cells also appeared to be enhanced.\u003cbr/\u003eHowever, the treatment need to be totally personalised, as the vaccines are created from each patient's own denditric cells and the specific HIV virus which has infected their immune system. \u003cbr/\u003eSOUNDBITE: (Spanish)\u003cbr/\u003e\"The vaccine is based on the patient's own denditric cells from the blood as well as the patient's own virus. So the vaccine is personal and it requires a medical centre to develop it. We still have to find easier ways to produce it by using dendritic cells and viruses other than those from the patient and make them work.\"\u003cbr/\u003eSUPER CAPTION: Teresa Gallart, head of vaccine project\u003cbr/\u003eThe Catalan scientists say they will be years of scientific and clinical research ahead before a vaccine can proven sufficiently effective and safe to be mass produced.\u003cbr/\u003eSOUNDBITE: (Spanish)\u003cbr/\u003e\"We have proved that a therapeutic vaccine is possible. Having said that, for all therapeutic vaccines, they all are in early stages. 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